Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 17/20 | 0.44 |
| ▸ | FLT1 | P17948 | 2/20 | 0.43 |
| ▸ | FLT4 | P35916 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3634899 | 0.81 | LMNA (0.44) | IMPDH2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3411154 | 0.79 | PSEN1 (0.43) | IMPDH2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3408093 | 0.78 | PSEN1 (0.44) | IMPDH2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2365517 | 0.77 | PSEN1 (0.63) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3411256 | 0.77 | ABCB1 (0.40) | IMPDH2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3407207 | 0.76 | PSEN1 (0.43) | IMPDH2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3410539 | 0.75 | MAPT (0.43) | IMPDH2IMPDH1 | |
| SCHEMBL3410455 | 0.75 | MEN1 (0.42) | IMPDH2FLT4KDRPSEN1PSEN2 | |
| SCHEMBL3410452 | 0.74 | BRAF (0.44) | IMPDH2 | |
| SCHEMBL3406191 | 0.73 | IMPDH2 (0.45) | IMPDH2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2355817-A1 | HETEROCYCLIC GAMMA SECRETASE MODULATORS | F. Hoffmann-La Roche AG (CH) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010052199-A1 | HETEROCYCLIC GAMMA SECRETASE MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-05-14 | — | — | WO | disclosed |