Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 8/20 | 0.45 |
| ▸ | PLK1 | P53350 | 4/20 | 0.43 |
| ▸ | KDR | P35968 | 5/20 | 0.43 |
| ▸ | CDK1 | P06493 | 4/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3410488 | 0.82 | BRD4 (0.40) | IMPDH2PLK1KDRCYP1A2 | |
| SCHEMBL3409949 | 0.82 | IMPDH2 (0.51) | IMPDH2 | |
| SCHEMBL3413376 | 0.81 | GAA (0.43) | IMPDH2KDRCDK1MEN1CYP1A2 | |
| SCHEMBL3410226 | 0.81 | PLK1 (0.47) | PLK1KDRCDK1 | |
| SCHEMBL3410455 | 0.80 | MEN1 (0.42) | IMPDH2PLK1KDRMEN1CYP1A2 | |
| SCHEMBL3412792 | 0.80 | KDR (0.48) | PLK1KDRCDK1MAPT | |
| SCHEMBL3410224 | 0.80 | TP53 (0.43) | PLK1KDRMEN1MAPTKMT2A | |
| SCHEMBL3413146 | 0.80 | IMPDH2 (0.40) | IMPDH2PLK1GSK3B | |
| SCHEMBL3412922 | 0.80 | IMPDH2 (0.39) | IMPDH2PLK1 | |
| SCHEMBL3408743 | 0.80 | PRKCA (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |