Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | WDR5 | P61964 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2331462 | 0.83 | CSNK2A1 (0.50) | MAPTALDH1A1NPSR1LMNAKMT2A | |
| SCHEMBL2324136 | 0.81 | NPSR1 (0.55) | MAPTALDH1A1NPSR1LMNAKMT2A | |
| SCHEMBL1040135 | 0.80 | MAPT (0.46) | MAPTALDH1A1LMNAKMT2ACYP1A2 | |
| SCHEMBL2325394 | 0.80 | PSEN1 (0.53) | KCNH2CYP3A4 | |
| SCHEMBL3637440 | 0.78 | TP53 (0.40) | MAPTALDH1A1LMNAKMT2AMAPK1 | |
| SCHEMBL3636568 | 0.78 | PLA2G7 (0.34) | MAPTKCNH2GRIN2BNAMPTPOLB | |
| SCHEMBL3633324 | 0.78 | CCNT1 (0.41) | MAPTALDH1A1NAMPTKMT2ARAB9A | |
| SCHEMBL3637805 | 0.75 | VCP (0.59) | MAPTALDH1A1NAMPTLMNAKMT2A | |
| SCHEMBL3634147 | 0.75 | MAPT (0.56) | MAPTALDH1A1LMNAKMT2AMAPK1 | |
| SCHEMBL2322931 | 0.74 | PSEN1 (0.45) | MAPTALDH1A1LMNAKMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2355817-A1 | HETEROCYCLIC GAMMA SECRETASE MODULATORS | F. Hoffmann-La Roche AG (CH) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010052199-A1 | HETEROCYCLIC GAMMA SECRETASE MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-05-14 | — | — | WO | disclosed |