Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GRK6 | P43250 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21624451 | 0.81 | SCN9A (0.44) | SCN9ACYP3A4FABP4 | |
| SCHEMBL29561873 | 0.81 | SCN9A (0.44) | SCN9ACYP3A4FABP4 | |
| SCHEMBL30241242 | 0.77 | FABP4 (0.45) | ALDH1A1SCN9ACYP3A4HPGDTRPV1 | |
| SCHEMBL17157028 | 0.76 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL4555403 | 0.76 | BRD4 (0.41) | SCN9ACYP3A4FABP4 | |
| SCHEMBL27710542 | 0.75 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2MAPTRAB9ATSHR | |
| SCHEMBL17594556 | 0.74 | SCN9A (0.39) | SCN9ACYP3A4FABP4 | |
| SCHEMBL29537150 | 0.74 | SCN9A (0.39) | SCN9ACYP3A4FABP4 | |
| SCHEMBL30339795 | 0.72 | FABP4 (0.58) | SCN9ALMNAFABP4 | |
| SCHEMBL530568 | 0.72 | FABP4 (0.58) | SCN9ALMNAFABP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761505-B1 | PYRIMIDINE UREA DERIVATIVES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2011-08-17 | — | — | EP | disclosed |