Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 8/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CD38 | P28907 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.35 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21624451 | 0.80 | SCN9A (0.44) | SCN9APARP1PDK2CYP3A4CD38 | |
| SCHEMBL29561873 | 0.80 | SCN9A (0.44) | SCN9APARP1PDK2CYP3A4CD38 | |
| SCHEMBL31620858 | 0.77 | LCK (0.62) | — | |
| SCHEMBL30241242 | 0.76 | FABP4 (0.45) | SCN9APARP1PDK2CYP3A4CD38 | |
| SCHEMBL4776516 | 0.76 | PARP1 (0.52) | SCN9APARP1PDK2KEAP1NFE2L2 | |
| SCHEMBL6173681 | 0.76 | PARP1 (0.52) | SCN9APARP1PDK2CYP3A4CD38 | |
| SCHEMBL2329707 | 0.76 | ALDH1A1 (0.46) | SCN9ACYP3A4FABP4 | |
| SCHEMBL4555401 | 0.75 | FABP4 (0.46) | SCN9APARP1PDK2CYP3A4CD38 | |
| SCHEMBL17594708 | 0.75 | SCN9A (0.43) | SCN9APARP1PDK2P2RX7AR | |
| SCHEMBL23648815 | 0.75 | LCK (0.49) | SCN9APARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121692-A1 | SUBSTITUTED HETEROCYCLES AS JANUS KINASE INHIBITORS | Incyte Corporation (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008079965-A1 | SUBSTITUTED HETEROCYCLES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2008-07-03 | — | — | WO | disclosed |