Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 13/20 | 0.55 |
| ▸ | CRBN | Q96SW2 | 13/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.49 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.49 |
| ▸ | TNF | P01375 | 1/20 | 0.48 |
| ▸ | IL1B | P01584 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.48 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.48 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 2/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29942621 | 1.00 | DDB1 (0.55) | DDB1CRBNHDAC1HDAC2HDAC3 | |
| SCHEMBL25036293 | 0.88 | DDB1 (0.58) | DDB1CRBNHDAC1HDAC2HDAC3 | |
| SCHEMBL23768486 | 0.82 | CRBN (0.55) | DDB1CRBNTNFIL1BTBXA2R | |
| SCHEMBL22834201 | 0.82 | CRBN (0.68) | DDB1CRBNHDAC1HDAC2HDAC3 | |
| SCHEMBL21333201 | 0.82 | CRBN (0.68) | DDB1CRBNHDAC1HDAC2HDAC3 | |
| SCHEMBL22326316 | 0.82 | CRBN (0.68) | DDB1CRBNHDAC1HDAC2HDAC3 | |
| SCHEMBL23772794 | 0.82 | DDB1 (0.69) | DDB1CRBNHDAC1HDAC2HDAC3 | |
| SCHEMBL20142514 | 0.82 | CRBN (0.68) | DDB1CRBNHDAC1HDAC2HDAC3 | |
| SCHEMBL22325167 | 0.82 | CRBN (0.68) | DDB1CRBNHDAC1HDAC2HDAC3 | |
| SCHEMBL20242552 | 0.82 | CRBN (0.68) | DDB1CRBNHDAC1HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114728936-A | Bifunctional compounds for the treatment of cancer | 豪夫迈·罗氏有限公司 | 2022-07-08 | — | — | CN | disclosed |
| WO-2021083949-A1 | BIFUNCTIONAL COMPOUNDS FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2021-05-06 | — | — | WO | disclosed |