Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | LMNA | P02545 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | WDR5 | P61964 | 1/20 | 0.38 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15662852 | 1.00 | MAPT (0.42) | MAPTHTR7HTR1AALDH1A1LMNA | |
| SCHEMBL345772 | 0.76 | MAPT (0.35) | MAPTHTR7HTR1AALDH1A1LMNA | |
| SCHEMBL345771 | 0.76 | MAPT (0.35) | MAPTHTR7HTR1AALDH1A1LMNA | |
| SCHEMBL16305327 | 0.75 | PDE3B (0.47) | HTR7ALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL2360962 | 0.74 | MAPT (0.52) | MAPTHTR7HTR1AALDH1A1LMNA | |
| SCHEMBL23538488 | 0.74 | SLC6A9 (0.46) | MAPTHTR7HTR1AALDH1A1LMNA | |
| SCHEMBL30207498 | 0.74 | SLC6A9 (0.46) | MAPTHTR7HTR1AALDH1A1LMNA | |
| SCHEMBL30207571 | 0.71 | ALDH1A1 (0.46) | MAPTHTR7ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL23783287 | 0.71 | ALDH1A1 (0.46) | MAPTHTR7ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL30619362 | 0.71 | HTR7 (0.49) | MAPTHTR7ALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2356108-B1 | CARBAMATE DERIVATIVES OF ALKYL-HETEROCYCLES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2014-10-15 | — | — | EP | disclosed |
| US-8716289-B2 | Carbamate derivatives of alkyl-heterocycles, preparation thereof and therapeutic use thereof | SANOFI (FR) | 2014-05-06 | — | — | US | disclosed |
| EP-2356108-A1 | CARBAMATE DERIVATIVES OF ALKYL-HETEROCYCLES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010055267-A1 | CARBAMATE DERIVATIVES OF ALKYL-HETEROCYCLES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-05-20 | — | — | WO | disclosed |