Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23312134 | 0.75 | SLC6A9 (0.32) | — | |
| SCHEMBL25911007 | 0.74 | MAPT (0.41) | MAPTGAATSHRSMN1; SMN2 | |
| SCHEMBL25691543 | 0.72 | SMN1; SMN2 (0.42) | MAPTGAATSHRSMN1; SMN2 | |
| SCHEMBL23278117 | 0.72 | SMN1; SMN2 (0.55) | MAPTGAATSHRSMN1; SMN2 | |
| SCHEMBL23444393 | 0.71 | SMN1; SMN2 (0.41) | MAPTGAATSHRSMN1; SMN2 | |
| SCHEMBL22704582 | 0.71 | SMN1; SMN2 (0.41) | MAPTGAATSHRSMN1; SMN2 | |
| SCHEMBL21565841 | 0.71 | SMN1; SMN2 (0.41) | MAPTGAATSHRSMN1; SMN2 | |
| SCHEMBL23569907 | 0.71 | SMN1; SMN2 (0.41) | MAPTGAATSHRSMN1; SMN2 | |
| SCHEMBL23323941 | 0.71 | SMN1; SMN2 (0.41) | MAPTGAATSHRSMN1; SMN2 | |
| SCHEMBL24536431 | 0.71 | L3MBTL1 (0.33) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021081212-A1 | PYRIDOPYRIMIDINE DERIVATIVES USEFUL AS KRAS G12C AND KRAS G12D INHIBITORS IN THE TREATMENT OF CANCER | AMGEN INC. (US) | 2021-04-29 | — | — | WO | disclosed |