Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23312135 | 0.81 | HRH3 (0.32) | HRH3EGLN1 | |
| SCHEMBL21867124 | 0.78 | HRH3 (0.36) | SLC6A9HRH3EGLN1 | |
| SCHEMBL25704492 | 0.78 | PIK3CD (0.40) | SLC6A9HRH3 | |
| SCHEMBL16257031 | 0.77 | GPX4 (0.38) | SLC6A9EGLN1 | |
| SCHEMBL23312170 | 0.75 | MAPT (0.43) | — | |
| SCHEMBL23312132 | 0.75 | SLC6A9 (0.31) | SLC6A9HRH3EGLN1 | |
| SCHEMBL23312164 | 0.74 | HRH3 (0.45) | HRH3RECQL | |
| SCHEMBL3857094 | 0.74 | CHRNB2 (0.45) | HRH3EGLN1 | |
| SCHEMBL3857098 | 0.74 | CHRNB2 (0.45) | HRH3EGLN1 | |
| SCHEMBL23876808 | 0.73 | MEN1 (0.36) | SLC6A9HRH3EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021081212-A1 | PYRIDOPYRIMIDINE DERIVATIVES USEFUL AS KRAS G12C AND KRAS G12D INHIBITORS IN THE TREATMENT OF CANCER | AMGEN INC. (US) | 2021-04-29 | — | — | WO | disclosed |