Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | NPC1 | O15118 | 2/20 | 0.66 |
| ▸ | THRB | P10828 | 1/20 | 0.66 |
| ▸ | HCRTR2 | O43614 | 8/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5471336 | 0.82 | KMT2A (0.70) | GPR183KMT2ANPC1THRBHCRTR2 | |
| SCHEMBL9668362 | 0.81 | CHRNA7 (0.69) | GPR183KMT2ANPC1THRBHCRTR2 | |
| SCHEMBL9667825 | 0.81 | CHRNA7 (0.69) | GPR183KMT2ANPC1THRBHCRTR2 | |
| SCHEMBL18766747 | 0.78 | HCRTR2 (0.70) | GPR183KMT2ANPC1THRBHCRTR2 | |
| SCHEMBL5786994 | 0.77 | GPR183 (0.63) | GPR183KDM4EALDH1A1LMNA | |
| SCHEMBL6326677 | 0.77 | HCRTR2 (0.76) | GPR183KMT2ANPC1HCRTR2HCRTR1 | |
| SCHEMBL6326918 | 0.77 | HCRTR2 (0.76) | GPR183KMT2ANPC1HCRTR2HCRTR1 | |
| SCHEMBL6324675 | 0.77 | HCRTR2 (0.76) | GPR183KMT2ANPC1HCRTR2HCRTR1 | |
| SCHEMBL3056571 | 0.77 | KDM4E (0.69) | GPR183KMT2ANPC1THRBHCRTR2 | |
| SCHEMBL4013019 | 0.76 | GPR183 (0.62) | GPR183KMT2ANPC1THRBHCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210122750-A1 | GPR183 ANTAGONISTS FOR THE TREATMENT OF PAIN | SAINT LOUIS UNIVERSITY | 2021-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210122750-A1 | GPR183 ANTAGONISTS FOR THE TREATMENT OF PAIN | OPRL1, GPR183, GPR65 | GPR183 2/4885KMT2A 4194/4885NPC1 977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.