Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.67 |
| ▸ | GPR183 | P32249 | 1/20 | 0.67 |
| ▸ | HCRTR2 | O43614 | 8/20 | 0.61 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.57 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9667825 | 1.00 | CHRNA7 (0.69) | CHRNA7KMT2ANPC1GPR183HCRTR2 | |
| SCHEMBL3056571 | 0.87 | KDM4E (0.69) | CHRNA7KMT2ANPC1GPR183HCRTR2 | |
| SCHEMBL9416605 | 0.86 | LMNA (0.75) | CHRNA7KMT2ANPC1GPR183HCRTR2 | |
| SCHEMBL9416631 | 0.85 | KMT2A (0.76) | CHRNA7KMT2ANPC1GPR183HCRTR2 | |
| SCHEMBL3041866 | 0.85 | KMT2A (0.62) | CHRNA7KMT2ANPC1GPR183HCRTR2 | |
| SCHEMBL3056740 | 0.85 | KMT2A (0.68) | CHRNA7KMT2ANPC1GPR183HCRTR2 | |
| SCHEMBL3056795 | 0.85 | KMT2A (0.62) | CHRNA7KMT2ANPC1GPR183HCRTR2 | |
| SCHEMBL7006650 | 0.83 | MAPK1 (0.65) | KMT2ANPC1HSD17B10KDM4EALOX15 | |
| SCHEMBL5471336 | 0.83 | KMT2A (0.70) | CHRNA7KMT2ANPC1GPR183HCRTR2 | |
| SCHEMBL3055130 | 0.83 | PDE4B (0.66) | CHRNA7KMT2ANPC1GPR183HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0308059-B1 | 1,2,3,4-TETRAHYDROISOQUINOLINE ANTIARRHYTHMIC AGENTS | Pfizer Limited (GB) | 1992-09-09 | — | — | EP | disclosed |
| US-4965360-A | Tetrahydroisoquinoline compounds | PFIZER INC. (US) | 1990-10-23 | — | — | US | disclosed |
| US-4882337-A | Tetrahydroisoquinoline antiarrhythmic agents | PFIZER INC. (US) | 1989-11-21 | — | — | US | disclosed |
| EP-0308059-A1 | 1,2,3,4-Tetrahydroisoquinoline antiarrhythmic agents | Pfizer Limited (GB) | 1989-03-22 | — | — | EP | disclosed |