Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.60 |
| ▸ | CA2 | P00918 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | P2RX1 | P51575 | 9/20 | 0.52 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.50 |
| ▸ | TMPRSS4 | Q9NRS4 | 7/20 | 0.49 |
| ▸ | P2RX4 | Q99571 | 5/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | IKBKB | O14920 | 1/20 | 0.49 |
| ▸ | CHUK | O15111 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | MYLK | Q15746 | 1/20 | 0.49 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10574930 | 0.87 | CA1 (0.58) | CA1CA2LMNAHTTKCNH2 | |
| SCHEMBL28475965 | 0.80 | CA12 (0.57) | CA1CA2LMNAHTTP2RX1 | |
| SCHEMBL13151996 | 0.79 | RECQL (0.53) | LMNAHTTKCNH2SMN1; SMN2KMT2A | |
| SCHEMBL12532565 | 0.78 | SMN1; SMN2 (0.59) | HTTSMN1; SMN2MEN1KMT2AKDR | |
| SCHEMBL26054350 | 0.78 | CSNK2A1 (0.62) | LMNAHTTSMN1; SMN2P2RX1TMPRSS4 | |
| SCHEMBL20968011 | 0.78 | HSP90AA1 (0.60) | LMNAHTTKCNH2SMN1; SMN2P2RX1 | |
| SCHEMBL28019535 | 0.78 | KDM4E (0.53) | CA1CA2LMNAHTTKCNH2 | |
| SCHEMBL218964 | 0.78 | CA1 (0.67) | CA1CA2LMNAHTTKCNH2 | |
| SCHEMBL6966672 | 0.77 | CA1 (0.72) | CA1CA2LMNAHTTSMN1; SMN2 | |
| SCHEMBL23313017 | 0.77 | P2RX1 (0.50) | CA1CA2LMNAHTTP2RX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10995061-B2 | SPAK kinase inhibitors as neuroprotective agents | UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (US) | 2021-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10995061-B2 | SPAK kinase inhibitors as neuroprotective agents | SBK1, DAPK2, SPAST | CA1 1530/4885CA2 1302/4885LMNA 1790/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.