Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.72 |
| ▸ | CA2 | P00918 | 1/20 | 0.72 |
| ▸ | P2RX1 | P51575 | 6/20 | 0.58 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | TMPRSS4 | Q9NRS4 | 3/20 | 0.56 |
| ▸ | P2RX4 | Q99571 | 3/20 | 0.56 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CASP1 | P29466 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28098623 | 0.90 | CA1 (0.60) | CA1CA2P2RX1KCNMA1PKM | |
| SCHEMBL5962842 | 0.90 | GSTA1 (0.62) | CA1CA2P2RX1KCNMA1PKM | |
| SCHEMBL9779330 | 0.87 | CA1 (0.62) | CA1CA2P2RX1KCNMA1TMPRSS4 | |
| SCHEMBL145258 | 0.87 | RECQL (0.70) | CA1CA2KCNMA1PKMGAA | |
| SCHEMBL14419305 | 0.86 | CA1 (0.60) | CA1CA2P2RX1KCNMA1PKM | |
| SCHEMBL9450719 | 0.85 | CA1 (0.70) | CA1CA2KCNMA1PKMGAA | |
| SCHEMBL29389634 | 0.84 | MAPT (0.66) | CA1CA2KCNMA1GAATMPRSS4 | |
| SCHEMBL95155 | 0.84 | MAPT (0.66) | CA1CA2KCNMA1GAATMPRSS4 | |
| 5-Chlorosalicylic Acid SCHEMBL29499764 | 0.84 | CA1 (1.00) | CA1CA2P2RX1KCNMA1PKM | |
| 5-Chlorosalicylic Acid SCHEMBL130605 | 0.84 | CA1 (1.00) | CA1CA2P2RX1KCNMA1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1129582-C | 3-substituted-4-arylquinolin-2-one derivatives as potassium channel modulators | BRISTOL MYERS SQUIBB CO (US) | 2003-12-03 | — | — | CN | disclosed |
| EP-0934312-B1 | 1,4-DISUBSTITUTED PIPERAZINES | NOVO NORDISK AS (DK) | 2003-03-19 | — | — | EP | disclosed |
| EP-0851865-B1 | 12H-Dibenzo[d,g][1,3]dioxocine derivatives | NOVO NORDISK AS (DK) | 2002-07-17 | — | — | EP | disclosed |
| CN-1329599-A | 3-substituted-4-arylquinolin-2-one derivatives as potassium channel modulators | BRISTOL MYERS SQUIBB CO (US) | 2002-01-02 | — | — | CN | disclosed |
| US-6133268-A | 1,4-disubstituted piperazines | NOVO NORDISK A/S (DK) | 2000-10-17 | — | — | US | disclosed |
| US-6040302-A | ANTIINFLAMMATORY AGENTS TREATING RHEUMATOID ARTHRITIS, MIGRAINE OR ITCHING, INSULIN RESISTANCE IN NON-INSULIN-DEPENDENT DIABETES MELLITUS AND AGEING-ASSOCIATED OBESITY | NOVO NORDISK A/S (DK) | 2000-03-21 | — | — | US | disclosed |
| US-6017915-A | Heterocyclic compounds | NOVO NORDISK A/S (DK) | 2000-01-25 | — | — | US | disclosed |
| US-6004961-A | ANTIINFLAMMATORY AGENTS, ANALGESICS; NON-INSULIN-DEPENDENT DIABETES; AGE-RELATED OBESITY; DIBENZO(D,G)(1,3,6)DIOXAZOCINE DERIVATIVES | NOVO NORDISK A/S (DK) | 1999-12-21 | — | — | US | disclosed |
| US-5972925-A | 1-(3-(2-CHLORO-12H-DIBENZO(D,G)(1,3,6)DIOXAZOCIN-12-YL)-1-PROP YL)-3-PIPERIDINECARBOXYLIC ACID, FOR EXAMPLE; TREATING NEUROGENIC PAIN (IN WHICH C-FIBERS PLAY A ROLE) OR INFLAMMATION SUCH AS MIGRAINE OR DIABETIC NEUROPATHY | NOVO NORDISK A/S (DK) | 1999-10-26 | — | — | US | disclosed |
| EP-0934312-A1 | 1,4-DISUBSTITUTED PIPERAZINES | NOVO NORDISK A/S (DK) | 1999-08-11 | — | — | EP | disclosed |
| US-5916901-A | CLINICAL TREATMENT OF PAINFUL, HYPERALGESIC, INFLAMMATORY CONDITIONS IN WHICH C-FIBERS PLAY A PATHOPHYSIOLOGICAL ROLE BY ELICITING NEUROGENIC PAIN | NOVO NORDISK A/S (DK) | 1999-06-29 | — | — | US | disclosed |
| US-5916889-A | ANTIDIABETIC AGENT; DIETETICS | NOVO NORDISK A/S (DK) | 1999-06-29 | — | — | US | disclosed |
| US-5917047-A | CLINICAL TREATMENT OF PAINFUL, HYPERALGESIC, INFLAMMATORY CONDITIONS IN WHICH C-FIBERS PLAY A PATHOPHYSIOLOGICAL ROLE BY ELICITING NEUROGENIC PAIN | NOVO NORDISK A/S (DK) | 1999-06-29 | — | — | US | disclosed |
| US-5912262-A | Heterocyclic compounds | NOVO NORDISH A/S (DK) | 1999-06-15 | — | — | US | disclosed |
| EP-0851865-A1 | NOVEL HETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 1998-07-08 | — | — | EP | disclosed |
| US-5753678-A | Heterocyclic compounds | NOVO NORDISK A/S (DK) | 1998-05-19 | — | — | US | disclosed |
| WO-1998015548-A1 | 1,4-DISUBSTITUTED PIPERAZINES | NOVO NORDISK A/S (DK) | 1998-04-16 | — | — | WO | disclosed |
| WO-1997011071-A1 | NOVEL HETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 1997-03-27 | — | — | WO | disclosed |
| US-4251546-A | Process for killing internal helminths using certain 1,1-bis-(2-substituted-3-nitrophenyl)alkane or alkylene derivatives | ICI AUSTRALIA LIMITED (AU) | 1981-02-17 | — | — | US | disclosed |