Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | ACHE | P22303 | 1/20 | 0.57 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | CCR3 | P51677 | 1/20 | 0.55 |
| ▸ | L3MBTL3 | Q96JM7 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.54 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.54 |
| ▸ | MCOLN1 | Q9GZU1 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2332802 | 0.98 | MAPT (0.65) | MAPTSIGMAR1HRH3SLC6A3KDM4E | |
| SCHEMBL2330002 | 0.91 | SIGMAR1 (0.67) | SIGMAR1HRH3TMEM97 | |
| Hydrochloric Acid SCHEMBL2328647 | 0.89 | SIGMAR1 (0.65) | SIGMAR1KDM4ETSHRTMEM97 | |
| SCHEMBL1299275 | 0.89 | SIGMAR1 (0.69) | MAPTSIGMAR1TMEM97L3MBTL3L3MBTL1 | |
| Hydrochloric Acid SCHEMBL1298985 | 0.88 | SIGMAR1 (0.67) | MAPTSIGMAR1KDM4ETSHRTMEM97 | |
| SCHEMBL7441175 | 0.86 | SIGMAR1 (0.66) | MAPTSIGMAR1HRH3SLC6A3KDM4E | |
| SCHEMBL16225992 | 0.84 | KMT2A (0.59) | SIGMAR1HRH3KDM4ETSHRKMT2A | |
| SCHEMBL2336883 | 0.83 | KDM4E (0.65) | SIGMAR1HRH3KDM4ETSHRACHE | |
| SCHEMBL27453569 | 0.83 | MAPT (0.70) | MAPTSIGMAR1SLC6A3KDM4ETSHR | |
| SCHEMBL27429046 | 0.83 | MAPT (0.74) | MAPTSIGMAR1SLC6A3KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102197028-A | Piperidine derivative and piperazine derivative, and therapeutic agent for diseases associated with central nervous system disorders | MS SCIENCE CORP | 2011-09-21 | — | — | CN | claimed |
| EP-2357171-A1 | PIPERIDINE DERIVATIVE, PIPERAZINE DERIVATIVE AND AGENT FOR TREATMENT OF DISEASE INVOLVING CENTRAL NERVOUS SYSTEM DISORDERS | M's Science Corporation (JP) | 2011-08-17 | — | — | EP | claimed |
| US-20110263862-A1 | PIPERIDINE DERIVATIVE, PIPERAZINE DERIVATIVE AND AGENT FOR TREATMENT OF DISEASE INVOLVING CENTRAL NERVOUS SYSTEM DISORDERS | M'S SCIENCE CORPORATION (JP) | 2011-10-27 | — | — | US | disclosed |
| US-20110263862-A1 | PIPERIDINE DERIVATIVE, PIPERAZINE DERIVATIVE AND AGENT FOR TREATMENT OF DISEASE INVOLVING CENTRAL NERVOUS SYSTEM DISORDERS | M'S SCIENCE CORPORATION (JP) | 2011-10-27 | — | — | US | disclosed |
| US-20110263862-A1 | PIPERIDINE DERIVATIVE, PIPERAZINE DERIVATIVE AND AGENT FOR TREATMENT OF DISEASE INVOLVING CENTRAL NERVOUS SYSTEM DISORDERS | M'S SCIENCE CORPORATION (JP) | 2011-10-27 | — | — | US | disclosed |
| CN-102197028-A | Piperidine derivative and piperazine derivative, and therapeutic agent for diseases associated with central nervous system disorders | MS SCIENCE CORP | 2011-09-21 | — | — | CN | disclosed |
| EP-2357171-A1 | PIPERIDINE DERIVATIVE, PIPERAZINE DERIVATIVE AND AGENT FOR TREATMENT OF DISEASE INVOLVING CENTRAL NERVOUS SYSTEM DISORDERS | M's Science Corporation (JP) | 2011-08-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263862-A1 | PIPERIDINE DERIVATIVE, PIPERAZINE DERIVATIVE AND AGENT FOR TREATMENT OF DISEASE INVOLVING CENTRAL NERVOUS SYSTEM DISORDERS | SIGMAR1, OPRL1, OPRK1 | MAPT 848/4885SIGMAR1 1/4885HRH3 139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.