Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.66 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.49 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.48 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.48 |
| ▸ | MCOLN1 | Q9GZU1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2331362 | 0.86 | MAPT (0.67) | SIGMAR1SLC6A3MAPTKDM4ETSHR | |
| Hydrochloric Acid SCHEMBL2332802 | 0.85 | MAPT (0.65) | SIGMAR1SLC6A3MAPTKDM4ETSHR | |
| SCHEMBL5091037 | 0.85 | SIGMAR1 (0.54) | SIGMAR1KDM4ETSHRHRH3CHRM1 | |
| SCHEMBL23225374 | 0.80 | ALDH1A1 (0.58) | SIGMAR1KDM4ETSHR | |
| SCHEMBL21216229 | 0.80 | ALDH1A1 (0.58) | SIGMAR1KDM4ETSHR | |
| SCHEMBL1299275 | 0.79 | SIGMAR1 (0.69) | SIGMAR1MAPTL3MBTL3L3MBTL1 | |
| SCHEMBL8643172 | 0.78 | SIGMAR1 (0.47) | SIGMAR1MAPTHRH3ACHE | |
| Hydrochloric Acid SCHEMBL1298985 | 0.78 | SIGMAR1 (0.67) | SIGMAR1MAPTKDM4ETSHRL3MBTL3 | |
| SCHEMBL2330002 | 0.78 | SIGMAR1 (0.67) | SIGMAR1HRH3 | |
| Hydrochloric Acid SCHEMBL2328647 | 0.77 | SIGMAR1 (0.65) | SIGMAR1KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5731307-A | Neuroleptic 2,7-disubtituted perhydro-1h-pyrido 1, 2-A!pyrazines | PFIZER, INC. (US) | 1998-03-24 | — | — | US | disclosed |
| WO-1996010570-A1 | NEUROLEPTIC 2,7-DISUBSTITUTED PERHYDRO-1H-PYRIDO[1,2-a]PYRAZINES | PFIZER INC. (US) | 1996-04-11 | — | — | WO | disclosed |