Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.43 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24921017 | 1.00 | ALDH1A1 (0.43) | ALDH1A1CRBNDDB1IKZF3TSHR | |
| SCHEMBL22151320 | 0.86 | IDO1 (0.39) | ALDH1A1CRBNDDB1IKZF3TSHR | |
| SCHEMBL23314121 | 0.77 | TSHR (0.42) | TSHRRAB9ANPC1CA1CA2 | |
| SCHEMBL24654288 | 0.77 | CRBN (0.50) | CRBNTSHRRAB9AMEN1KMT2A | |
| SCHEMBL24761802 | 0.77 | CRBN (0.50) | CRBNTSHRRAB9AMEN1KMT2A | |
| SCHEMBL20076190 | 0.76 | CA12 (0.30) | CA9 | |
| SCHEMBL11422629 | 0.76 | ALDH1A1 (0.47) | ALDH1A1CRBNDDB1IKZF3TSHR | |
| SCHEMBL22047669 | 0.74 | CRBN (0.43) | ALDH1A1CRBNDDB1IKZF3TSHR | |
| SCHEMBL25059011 | 0.73 | CASP3 (0.43) | ALDH1A1CRBNDDB1IKZF3TSHR | |
| SCHEMBL17162092 | 0.72 | CRBN (0.50) | ALDH1A1CRBNDDB1IKZF3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10994015-B2 | EGFR proteolysis targeting chimeric molecules and associated methods of use | ARVINAS OPERATIONS, INC. (US) | 2021-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10994015-B2 | EGFR proteolysis targeting chimeric molecules and associated methods of use | EGFR, ERBB2, ERBB3 | ALDH1A1 3751/4885CRBN 47/4885DDB1 974/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.