Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19841461 | 1.00 | MCL1 (0.34) | MCL1LMNAOPRM1OPRL1ALOX15 | |
| SCHEMBL23587946 | 0.92 | CTSD (0.35) | MCL1LMNA | |
| SCHEMBL21846058 | 0.85 | CA1 (0.32) | — | |
| SCHEMBL16312954 | 0.84 | TDP1 (0.32) | LMNAALOX15TSHRCYP2C19TDP1 | |
| SCHEMBL13166148 | 0.84 | TDP1 (0.52) | LMNAALOX15TSHRCYP2C19TDP1 | |
| SCHEMBL23316914 | 0.83 | HTR7 (0.31) | — | |
| SCHEMBL19058025 | 0.82 | TDP1 (0.31) | LMNAALOX15TSHRCYP2C19TDP1 | |
| SCHEMBL19057947 | 0.82 | TDP1 (0.31) | LMNAALOX15TSHRCYP2C19TDP1 | |
| SCHEMBL23317022 | 0.82 | KDM4E (0.40) | — | |
| SCHEMBL19841396 | 0.81 | CTSD (0.41) | MCL1LMNAOPRM1OPRL1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091441-A1 | GLUCOSE-RESPONSIVE INSULIN CONJUGATES COMPRISING A TETRA-VALENT SUGAR CLUSTER FOR TREATMENT OF DIABETES | MERCK SHARP & DOHME LLC (US) | 2023-05-25 | — | — | WO | disclosed |
| EP-3052134-B1 | GLUCOSE-RESPONSIVE INSULIN CONJUGATES | MERCK SHARP & DOHME (US) | 2021-05-05 | — | — | EP | disclosed |