Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | TACR1 | P25103 | 1/20 | 0.30 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15720203 | 0.84 | L3MBTL1 (0.38) | TSHRGFERAPEX1BLMOPRM1 | |
| SCHEMBL15719924 | 0.77 | TSHR (0.36) | TSHRGFERAPEX1BLMATM | |
| SCHEMBL16058256 | 0.75 | L3MBTL1 (0.36) | APEX1BLMOPRM1OPRL1L3MBTL1 | |
| SCHEMBL17474301 | 0.74 | APEX1 (0.34) | TSHRAPEX1BLMOPRM1OPRL1 | |
| SCHEMBL15719231 | 0.74 | TACR1 (0.45) | TSHRSMN1; SMN2TACR1 | |
| SCHEMBL4575280 | 0.74 | TSHR (0.65) | TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL2334268 | 0.72 | TSHR (0.32) | TSHRGFERAPEX1BLMOPRM1 | |
| SCHEMBL16059156 | 0.70 | APEX1 (0.36) | TSHRAPEX1BLML3MBTL1POLB | |
| SCHEMBL16061700 | 0.70 | ALDH1A1 (0.33) | TSHRGFERATML3MBTL1ALDH1A1 | |
| SCHEMBL16058765 | 0.70 | GFER (0.37) | GFERATML3MBTL1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2533645-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | The Johns Hopkins University (US) | 2012-12-19 | — | — | EP | disclosed |
| WO-2011100373-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-08-18 | — | — | WO | disclosed |