Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP2 | P42575 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 4/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.45 |
| ▸ | NAAA | Q02083 | 1/20 | 0.44 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25793668 | 0.95 | CASP2 (0.47) | CASP2NAMPTFAAHHDAC3HDAC4 | |
| SCHEMBL10345306 | 0.88 | NAMPT (0.52) | CASP2NAMPTFAAHNAAADNM1 | |
| SCHEMBL10345059 | 0.88 | NAMPT (0.52) | CASP2NAMPTFAAHNAAADNM1 | |
| SCHEMBL24818366 | 0.88 | NAMPT (0.52) | CASP2NAMPTFAAHNAAADNM1 | |
| SCHEMBL10660707 | 0.88 | NAMPT (0.52) | CASP2NAMPTFAAHNAAADNM1 | |
| SCHEMBL23843180 | 0.85 | CASP2 (0.65) | CASP2FAAHNAAADNM1CNR1 | |
| SCHEMBL10344999 | 0.85 | CASP2 (0.65) | CASP2FAAHNAAADNM1CNR1 | |
| SCHEMBL24810920 | 0.85 | CASP2 (0.65) | CASP2FAAHNAAADNM1CNR1 | |
| SCHEMBL10345080 | 0.85 | CASP2 (0.65) | CASP2FAAHNAAADNM1CNR1 | |
| SCHEMBL10345070 | 0.85 | CASP2 (0.65) | CASP2FAAHNAAADNM1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11634450-B2 | DOT1L degraders and uses thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-04-25 | — | — | US | disclosed |
| US-20210130386-A1 | DOT1L DEGRADERS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210130386-A1 | DOT1L DEGRADERS AND USES THEREOF | CRBN, CUL1, STUB1 | CASP2 2674/4885NAMPT 3106/4885FAAH 4288/4885 |
| US-11634450-B2 | DOT1L degraders and uses thereof | CRBN, CUL1, STUB1 | CASP2 2674/4885NAMPT 3106/4885FAAH 4288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.