Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 5/20 | 0.81 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23320389 | 0.90 | NAMPT (1.00) | NAMPTROCK2ROCK1IMPDH2HTT | |
| SCHEMBL24042588 | 0.78 | NAMPT (0.77) | NAMPTROCK2ROCK1SMN1; SMN2RAB9A | |
| SCHEMBL23320366 | 0.78 | NAMPT (0.66) | NAMPTROCK2ROCK1KDM4ESMN1; SMN2 | |
| SCHEMBL30943229 | 0.76 | NAMPT (0.75) | NAMPTROCK2ROCK1IMPDH2 | |
| SCHEMBL30943213 | 0.76 | NAMPT (0.75) | NAMPT | |
| SCHEMBL23320533 | 0.76 | NAMPT (0.75) | NAMPTROCK2ROCK1IMPDH2 | |
| SCHEMBL23320417 | 0.76 | NAMPT (0.75) | NAMPT | |
| SCHEMBL23320451 | 0.76 | NAMPT (0.69) | NAMPT | |
| SCHEMBL23320455 | 0.76 | ROCK2 (0.50) | NAMPTPRMT3ROCK2ROCK1KDM4E | |
| SCHEMBL11615935 | 0.76 | ROCK2 (0.79) | NAMPTPRMT3ROCK2ROCK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3818053-A1 | FUSED RING COMPOUND HAVING UREA STRUCTURE | Sanford Burnham Prebys Medical Discovery Institute (US) | 2021-05-12 | — | — | EP | claimed |
| EP-3818053-A1 | FUSED RING COMPOUND HAVING UREA STRUCTURE | Sanford Burnham Prebys Medical Discovery Institute (US) | 2021-05-12 | — | — | EP | disclosed |