Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23320389 | 0.79 | NAMPT (1.00) | NAMPTROCK2ROCK1ADORA3 | |
| SCHEMBL23320367 | 0.78 | NAMPT (0.81) | NAMPTROCK2ROCK1KMT2ANPC1 | |
| SCHEMBL23320454 | 0.76 | ALDH1A1 (0.48) | NAMPTALDH1A1TSHRHSD17B10ROCK2 | |
| SCHEMBL11615932 | 0.76 | HSD17B10 (0.79) | NAMPTALDH1A1TSHRHSD17B10ROCK2 | |
| SCHEMBL4531077 | 0.71 | HSD17B10 (0.70) | NAMPTALDH1A1TSHRHSD17B10ROCK2 | |
| SCHEMBL4519247 | 0.71 | HSD17B10 (0.70) | NAMPTALDH1A1TSHRHSD17B10ROCK2 | |
| SCHEMBL23320400 | 0.71 | NAMPT (0.66) | NAMPTALDH1A1TSHRHSD17B10ROCK2 | |
| SCHEMBL23320451 | 0.70 | NAMPT (0.69) | NAMPT | |
| SCHEMBL24042588 | 0.70 | NAMPT (0.77) | NAMPTALDH1A1ROCK2ROCK1GAA | |
| SCHEMBL3641867 | 0.70 | ALDH1A1 (0.54) | NAMPTALDH1A1HSD17B10GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3818053-A1 | FUSED RING COMPOUND HAVING UREA STRUCTURE | Sanford Burnham Prebys Medical Discovery Institute (US) | 2021-05-12 | — | — | EP | claimed |
| EP-3818053-A1 | FUSED RING COMPOUND HAVING UREA STRUCTURE | Sanford Burnham Prebys Medical Discovery Institute (US) | 2021-05-12 | — | — | EP | disclosed |