Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.50 |
| ▸ | NAMPT | P43490 | 2/20 | 0.48 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KHK | P50053 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23320353 | 0.91 | NAMPT (0.60) | ROCK2ROCK1NAMPTHTT | |
| SCHEMBL23320448 | 0.80 | PRMT3 (0.48) | ROCK2ROCK1NAMPTPRMT3KDM4E | |
| SCHEMBL23320454 | 0.80 | ALDH1A1 (0.48) | ROCK2ROCK1NAMPTKDM4EMAPK13 | |
| SCHEMBL23320440 | 0.76 | NAMPT (0.63) | ROCK2ROCK1NAMPTKHKRAB9A | |
| SCHEMBL23320367 | 0.76 | NAMPT (0.81) | ROCK2ROCK1NAMPTPRMT3KDM4E | |
| SCHEMBL23320377 | 0.76 | NAMPT (0.45) | NAMPT | |
| SCHEMBL11615935 | 0.72 | ROCK2 (0.79) | ROCK2ROCK1NAMPTPRMT3KDM4E | |
| SCHEMBL23320372 | 0.71 | NAMPT (0.60) | ROCK2ROCK1NAMPTHTT | |
| SCHEMBL23320357 | 0.71 | NAMPT (0.56) | ROCK2ROCK1NAMPTHTT | |
| SCHEMBL15140925 | 0.68 | ROCK2 (1.00) | ROCK2ROCK1NAMPTPRMT3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3818053-A1 | FUSED RING COMPOUND HAVING UREA STRUCTURE | Sanford Burnham Prebys Medical Discovery Institute (US) | 2021-05-12 | — | — | EP | disclosed |