Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 4/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28922327 | 1.00 | LMNA (0.56) | LMNACYP3A4MEN1CYP2D6CYP2C9 | |
| SCHEMBL30943258 | 0.84 | LMNA (0.56) | LMNACYP3A4CYP19A1MAOBABCB1 | |
| SCHEMBL28622408 | 0.83 | MAPT (0.49) | LMNACYP3A4MEN1CYP2D6CYP2C9 | |
| SCHEMBL17708871 | 0.81 | AR (0.67) | LMNACYP3A4MEN1CYP2D6CYP2C9 | |
| SCHEMBL1820849 | 0.81 | AR (0.67) | LMNACYP3A4MEN1CYP2D6CYP2C9 | |
| SCHEMBL23320569 | 0.79 | LMNA (0.54) | LMNACYP3A4HIF1ACYP19A1MAOB | |
| SCHEMBL20928443 | 0.78 | FFAR1 (0.40) | CYP3A4KMT2AMAOBALDH1A1MAPT | |
| SCHEMBL22882748 | 0.76 | FFAR1 (0.49) | LMNACYP3A4CYP19A1MAOBABCB1 | |
| SCHEMBL30943239 | 0.74 | LMNA (0.48) | LMNAMEN1KMT2ACYP19A1ALDH1A1 | |
| SCHEMBL30323931 | 0.74 | LMNA (0.48) | LMNAMEN1KMT2ACYP19A1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3818053-A1 | FUSED RING COMPOUND HAVING UREA STRUCTURE | Sanford Burnham Prebys Medical Discovery Institute (US) | 2021-05-12 | — | — | EP | disclosed |