Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 8/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.52 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23320512 | 0.89 | NAMPT (0.74) | NAMPTROCK2ROCK1RAB9AALDH1A1 | |
| SCHEMBL23320516 | 0.86 | NAMPT (0.82) | NAMPTKDM4EROCK2ROCK1PRMT3 | |
| SCHEMBL28620099 | 0.77 | NAMPT (0.73) | NAMPTRAB9AKMT2AALDH1A1 | |
| SCHEMBL23320480 | 0.76 | ALDH1A1 (0.53) | NAMPTROCK2ROCK1MEN1KMT2A | |
| SCHEMBL23320444 | 0.75 | NAMPT (1.00) | NAMPTPRMT3RAB9AKMT2AALDH1A1 | |
| SCHEMBL11615935 | 0.73 | ROCK2 (0.79) | NAMPTKDM4EROCK2ROCK1PRMT3 | |
| SCHEMBL30943224 | 0.72 | NAMPT (0.84) | NAMPTROCK2ROCK1 | |
| SCHEMBL24042554 | 0.72 | NAMPT (0.84) | NAMPTROCK2ROCK1 | |
| SCHEMBL18317382 | 0.72 | KDM4E (0.76) | NAMPTKDM4EROCK2ROCK1PRMT3 | |
| SCHEMBL23320402 | 0.72 | NAMPT (0.81) | NAMPTKDM4EROCK2ROCK1PRMT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3818053-A1 | FUSED RING COMPOUND HAVING UREA STRUCTURE | Sanford Burnham Prebys Medical Discovery Institute (US) | 2021-05-12 | — | — | EP | disclosed |