Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NAAA | Q02083 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LYPLA1 | O75608 | 1/20 | 0.40 |
| ▸ | LYPLA2 | O95372 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28428860 | 1.00 | TSHR (0.56) | TSHRKDM4EPOLBHTTALDH1A1 | |
| SCHEMBL12013320 | 0.96 | TSHR (0.52) | TSHRKDM4EPOLBHTTALDH1A1 | |
| SCHEMBL10622030 | 0.91 | HTT (0.49) | TSHRKDM4EPOLBHTTALDH1A1 | |
| SCHEMBL31036611 | 0.91 | TSHR (0.46) | TSHRKDM4EHTTLMNAHSD17B10 | |
| SCHEMBL12531323 | 0.90 | DRD1 (0.46) | TSHRKDM4EHTTALDH1A1LMNA | |
| SCHEMBL28420914 | 0.83 | CA1 (0.50) | TSHRALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL31482290 | 0.83 | TSHR (0.39) | TSHRKDM4EPOLBHTTALDH1A1 | |
| SCHEMBL22319935 | 0.82 | ALDH1A1 (0.50) | TSHRKDM4EPOLBHTTALDH1A1 | |
| SCHEMBL30997661 | 0.81 | TSHR (0.56) | TSHRHTTNAAASMN1; SMN2LYPLA1 | |
| SCHEMBL7134224 | 0.81 | TSHR (0.56) | TSHRKDM4EPOLBNAAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110243892-A1 | Y-SHAPE BRANCHED HYDROPHILIC POLYMER DERIVATIVES, THEIR PREPARATION METHODS, CONJUGATES OF THE DERIVATIVES AND DRUG MOLECULES, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE CONJUGATES | JI SHISHAN | 2011-10-06 | — | — | US | claimed |
| EP-1496076-B1 | HYDROPHILIC POLYMER DERIVATE WITH Y TYPE BRANCH AND PREPARATION METHOD OF IT MEDICAL COMPOSITE COMPRISING ABOVE COMPOUND | BEIJING JIANKAI TECHNOLOGY CO (CN) | 2007-07-25 | — | — | EP | claimed |
| US-20050180946-A1 | Hydrophilic polymer derivative with y type branch and preparation method of it medical cpmposite comprising above compund | BEIJING JIANKAI TECHNOLOGY CO., LTD. (CN) | 2005-08-18 | — | — | US | claimed |
| EP-1496076-A1 | HYDROPHILIC POLYMER DERIVATE WITH Y TYPE BRANCH AND PREPARATION METHOD OF IT MEDICAL COMPOSITE COMPRISING ABOVE COMPOUND | Beijing Jiankai Technology Co., Ltd. (CN) | 2005-01-12 | — | — | EP | claimed |
| US-20110243892-A1 | Y-SHAPE BRANCHED HYDROPHILIC POLYMER DERIVATIVES, THEIR PREPARATION METHODS, CONJUGATES OF THE DERIVATIVES AND DRUG MOLECULES, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE CONJUGATES | JI SHISHAN | 2011-10-06 | — | — | US | disclosed |
| US-20110243892-A1 | Y-SHAPE BRANCHED HYDROPHILIC POLYMER DERIVATIVES, THEIR PREPARATION METHODS, CONJUGATES OF THE DERIVATIVES AND DRUG MOLECULES, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE CONJUGATES | JI SHISHAN | 2011-10-06 | — | — | US | disclosed |
| US-8003089-B2 | such as triethanolamine with 2 hydroxyethyl groups derivatized with polyethylene glycol, and the amine group conjugated to drugs such as antitumor agent interferon | BEIJING JIANKAI TECHNOLOGY CO., LTD. (CN) | 2011-08-23 | — | — | US | disclosed |
| US-8003089-B2 | such as triethanolamine with 2 hydroxyethyl groups derivatized with polyethylene glycol, and the amine group conjugated to drugs such as antitumor agent interferon | BEIJING JIANKAI TECHNOLOGY CO., LTD. (CN) | 2011-08-23 | — | — | US | disclosed |
| US-20100221213-A1 | Y-SHAPE BRANCHED HYDROPHILIC POLYMER DERIVATIVES, THEIR PREPARATION METHODS, CONJUGATES OF THE DERIVATIVES AND DRUG MOLECULES, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE CONJUGATES | JI SHISHAN | 2010-09-02 | — | — | US | disclosed |
| US-20100221213-A1 | Y-SHAPE BRANCHED HYDROPHILIC POLYMER DERIVATIVES, THEIR PREPARATION METHODS, CONJUGATES OF THE DERIVATIVES AND DRUG MOLECULES, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE CONJUGATES | JI SHISHAN | 2010-09-02 | — | — | US | disclosed |
| EP-1496076-B1 | HYDROPHILIC POLYMER DERIVATE WITH Y TYPE BRANCH AND PREPARATION METHOD OF IT MEDICAL COMPOSITE COMPRISING ABOVE COMPOUND | BEIJING JIANKAI TECHNOLOGY CO (CN) | 2007-07-25 | — | — | EP | disclosed |
| EP-1496076-B1 | HYDROPHILIC POLYMER DERIVATE WITH Y TYPE BRANCH AND PREPARATION METHOD OF IT MEDICAL COMPOSITE COMPRISING ABOVE COMPOUND | BEIJING JIANKAI TECHNOLOGY CO (CN) | 2007-07-25 | — | — | EP | disclosed |
| US-20050180946-A1 | Hydrophilic polymer derivative with y type branch and preparation method of it medical cpmposite comprising above compund | BEIJING JIANKAI TECHNOLOGY CO., LTD. (CN) | 2005-08-18 | — | — | US | disclosed |
| EP-1496076-A1 | HYDROPHILIC POLYMER DERIVATE WITH Y TYPE BRANCH AND PREPARATION METHOD OF IT MEDICAL COMPOSITE COMPRISING ABOVE COMPOUND | Beijing Jiankai Technology Co., Ltd. (CN) | 2005-01-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050180946-A1 | Hydrophilic polymer derivative with y type branch and preparation method of it medical cpmposite comprising above compund | SLC10A2, FLT3, PGF | TSHR 1288/4885KDM4E 1446/4885POLB 1465/4885 |
| US-20100221213-A1 | Y-SHAPE BRANCHED HYDROPHILIC POLYMER DERIVATIVES, THEIR PREPARATION METHODS, CONJUGATES OF THE DERIVATIVES AND DRUG MOLECULES, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE CONJUGATES | EGFR, NPY5R, NPY4R | TSHR 1401/4885KDM4E 340/4885POLB 2847/4885 |
| US-20110243892-A1 | Y-SHAPE BRANCHED HYDROPHILIC POLYMER DERIVATIVES, THEIR PREPARATION METHODS, CONJUGATES OF THE DERIVATIVES AND DRUG MOLECULES, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE CONJUGATES | EGFR, NPY5R, NPY4R | TSHR 1401/4885KDM4E 340/4885POLB 2847/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.