Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.40 |
| ▸ | CTSS | P25774 | 2/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25976304 | 0.90 | PTPN1 (0.42) | SYKPTPN1PPARABCL2AAK1 | |
| SCHEMBL31314669 | 0.90 | PTPN1 (0.42) | SYKPTPN1PPARABCL2AAK1 | |
| SCHEMBL22703470 | 0.90 | PTPN1 (0.42) | SYKPTPN1PPARABCL2AAK1 | |
| SCHEMBL31314662 | 0.82 | AAK1 (0.38) | SYKPTPN1PPARABCL2AAK1 | |
| SCHEMBL29334447 | 0.79 | NPC1 (0.40) | MAPTCYP2D6MEN1KMT2A | |
| SCHEMBL27984256 | 0.78 | SYK (0.51) | SYKPPARACTSSCTSKMAPT | |
| SCHEMBL9608914 | 0.77 | CTSK (0.56) | SYKFAAHCTSSCTSKMAPT | |
| SCHEMBL5212724 | 0.77 | CTSK (0.56) | SYKFAAHCTSSCTSKMAPT | |
| SCHEMBL12203909 | 0.77 | CTSK (0.56) | SYKFAAHCTSSCTSKMAPT | |
| Hydrochloric Acid SCHEMBL31314675 | 0.76 | GHSR (0.42) | AAK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021086995-A1 | RNAI AGENTS FOR INHIBITING EXPRESSION OF BETA-ENAC, COMPOSITIONS THEREOF, AND METHODS OF USE | Arrowhead Pharmaceuticals, Inc. (US) | 2021-05-06 | — | — | WO | disclosed |