Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | AIP | O00170 | 1/20 | 0.46 |
| ▸ | SGTA | O43765 | 1/20 | 0.46 |
| ▸ | TOMM70 | O94826 | 1/20 | 0.46 |
| ▸ | STIP1 | P31948 | 1/20 | 0.46 |
| ▸ | PPP5C | P53041 | 1/20 | 0.46 |
| ▸ | FKBP4 | Q02790 | 1/20 | 0.46 |
| ▸ | PPID | Q08752 | 1/20 | 0.46 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.46 |
| ▸ | FKBP8 | Q14318 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23323376 | 0.90 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL23325009 | 0.87 | AIP (0.46) | ALDH1A1SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL26296832 | 0.72 | CYP1A2 (0.43) | ALDH1A1SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL26296197 | 0.71 | CYP1A2 (0.71) | ALDH1A1SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL1622930 | 0.66 | MAPK1 (0.78) | ALDH1A1HPGDCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8290398 | 0.65 | ALDH1A1 (0.77) | ALDH1A1HPGDCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL12115502 | 0.65 | ALDH1A1 (0.72) | ALDH1A1SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL26295499 | 0.65 | EPHB4 (0.39) | ALDH1A1SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL11324603 | 0.64 | AIP (0.66) | ALDH1A1SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL1926572 | 0.62 | MAPT (0.48) | ALDH1A1SMN1; SMN2NPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021087408-A1 | OTIC FORMULATIONS FOR DRUG-INDUCED OTOTOXICITY | OTONOMY, INC. (US) | 2021-05-06 | — | — | WO | disclosed |