Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26296197 | 0.76 | CYP1A2 (0.71) | CYP1A2ALDH1A1SMN1; SMN2HPGDMAPT | |
| SCHEMBL23323376 | 0.73 | ALDH1A1 (0.46) | CYP1A2ALDH1A1SMN1; SMN2HPGDMAPT | |
| SCHEMBL23323474 | 0.72 | ALDH1A1 (0.47) | CYP1A2ALDH1A1SMN1; SMN2HPGDMAPT | |
| SCHEMBL23325009 | 0.71 | AIP (0.46) | CYP1A2ALDH1A1SMN1; SMN2HPGDMAPT | |
| SCHEMBL17022059 | 0.68 | KCNH2 (0.47) | ALDH1A1SMN1; SMN2HPGDMAPTKDM4E | |
| SCHEMBL28068800 | 0.67 | POLB (0.39) | CYP1A2ALDH1A1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL21347384 | 0.67 | NPC1 (0.42) | CYP1A2ALDH1A1SMN1; SMN2HPGDMAPT | |
| SCHEMBL18015404 | 0.66 | MEN1 (0.55) | ALDH1A1SMN1; SMN2HPGDMAPTKDM4E | |
| SCHEMBL17022065 | 0.66 | CYP1A2 (0.41) | CYP1A2ALDH1A1SMN1; SMN2HPGDMAPT | |
| SCHEMBL14980643 | 0.63 | PLK1 (0.33) | ALDH1A1KMT2AMEN1POLBHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230293524-A1 | OTIC FORMULATIONS FOR DRUG-INDUCED OTOTOXICITY | SPIRAL THERAPEUTICS INC. | 2023-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230293524-A1 | OTIC FORMULATIONS FOR DRUG-INDUCED OTOTOXICITY | OTC, SLC26A4, OAT | CYP1A2 985/4885ALDH1A1 121/4885SMN1; SMN2 2074/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.