Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 6/20 | 0.59 |
| ▸ | HPGD | P15428 | 6/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29725974 | 0.79 | CNR2 (0.60) | CYP1A2ALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL12632684 | 0.77 | ALDH1A1 (0.68) | CYP1A2ALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL17817446 | 0.77 | CYP1A2 (0.61) | CYP1A2ALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL26296832 | 0.76 | CYP1A2 (0.43) | CYP1A2ALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL14825171 | 0.74 | PKM (0.63) | CYP1A2ALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL18177319 | 0.74 | PKM (1.00) | CYP1A2ALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL18180849 | 0.74 | ALDH1A1 (0.66) | CYP1A2ALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL3452499 | 0.73 | CYP1A2 (0.55) | CYP1A2ALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL1622930 | 0.73 | MAPK1 (0.78) | CYP1A2ALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL14305225 | 0.72 | ALDH1A1 (0.63) | CYP1A2ALDH1A1KDM4EMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230293524-A1 | OTIC FORMULATIONS FOR DRUG-INDUCED OTOTOXICITY | SPIRAL THERAPEUTICS INC. | 2023-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230293524-A1 | OTIC FORMULATIONS FOR DRUG-INDUCED OTOTOXICITY | OTC, SLC26A4, OAT | CYP1A2 985/4885ALDH1A1 121/4885KDM4E 4100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.