SCHEMBL2332409

SCHEMBL2332409

COc1cc(C=O)ccc1OCCC1CCCN1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FDPS P14324 1/20 0.60
MAPT P10636 9/20 0.51
LMNA P02545 3/20 0.51
SMN1; SMN2 Q16637 3/20 0.51
NPSR1 Q6W5P4 2/20 0.51
HTT P42858 2/20 0.51
ALDH1A1 P00352 9/20 0.49
TSHR P16473 1/20 0.49
HPGD P15428 8/20 0.48
CHRNB4 P30926 2/20 0.48
CHRNA3 P32297 2/20 0.48
CYP2C9 P11712 3/20 0.47
CYP1A2 P05177 2/20 0.47
CYP2C19 P33261 2/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
CYP2D6 P10635 1/20 0.47
KDM4E B2RXH2 1/20 0.47
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
CHEK1 O14757 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29038406 0.96 FDPS (0.59) FDPSMAPTLMNASMN1; SMN2NPSR1
SCHEMBL29038394 0.95 FDPS (0.53) FDPSMAPTLMNASMN1; SMN2NPSR1
SCHEMBL2172629 0.81 CHRNB4 (0.51) MAPTHTTALDH1A1TSHRHPGD
SCHEMBL1300120 0.80 FDPS (0.67) FDPSMAPTLMNASMN1; SMN2NPSR1
SCHEMBL2330776 0.80 CHRNB4 (0.50) HTTHPGDCHRNB4CHRNA3KDM4E
SCHEMBL11456174 0.79 CHRNB4 (0.74) ALDH1A1CHRNB4CHRNA3L3MBTL1CHEK1
SCHEMBL4201146 0.79 MAPK1 (0.54) HPGDCHRNB4CHRNA3KDM4ECHEK1
SCHEMBL11457361 0.79 CHRNB4 (0.54) CHRNB4CHRNA3CHEK1
SCHEMBL2332290 0.78 LTA4H (0.47) MAPTLMNASMN1; SMN2ALDH1A1HPGD
SCHEMBL6073607 0.78 CHRNB4 (0.47) MAPTSMN1; SMN2HPGDCHRNB4CHRNA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2536706-A1 ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME Celgene Corporation (US) 2012-12-26 EP disclosed
WO-2011100380-A1 ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME CELGENE CORPORATION (US) 2011-08-18 WO disclosed