Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 10/20 | 0.47 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3580473 | 0.96 | LTA4H (0.48) | LTA4HHPGDALDH1A1LMNAMAPT | |
| SCHEMBL2482746 | 0.81 | NFE2L2 (0.58) | LTA4HCHEK2 | |
| SCHEMBL7956624 | 0.81 | LTA4H (0.48) | LTA4HCHEK2 | |
| SCHEMBL11456190 | 0.81 | LTA4H (0.48) | LTA4H | |
| SCHEMBL11447699 | 0.81 | LTA4H (0.61) | LTA4H | |
| SCHEMBL11447734 | 0.81 | LTA4H (0.67) | LTA4H | |
| SCHEMBL11457974 | 0.81 | CHRNB4 (0.49) | LTA4H | |
| SCHEMBL11455721 | 0.81 | LTA4H (0.48) | LTA4H | |
| SCHEMBL11448511 | 0.81 | CHRNA3 (0.50) | LTA4HCHEK2 | |
| SCHEMBL6610063 | 0.80 | LTA4H (0.57) | LTA4HHRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2892537-A1 | METHODS FOR THE TREATMENT OF LOCALLY ADVANCED BREAST CANCER | Celgene Corporation (US) | 2015-07-15 | — | — | EP | disclosed |
| WO-2014039960-A1 | METHODS FOR THE TREATMENT OF LOCALLY ADVANCED BREAST CANCER | CELGENE CORPORATION (US) | 2014-03-13 | — | — | WO | disclosed |
| EP-2536706-A1 | ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | Celgene Corporation (US) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011100380-A1 | ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | CELGENE CORPORATION (US) | 2011-08-18 | — | — | WO | disclosed |