Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Chlorpromazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 5/20 | 1.00 |
| ▸ | DRD3 known ✓ | P35462 | 5/20 | 0.97 |
| ▸ | DRD4 known ✓ | P21917 | 3/20 | 0.97 |
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 9/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 9/20 | 1.00 |
| ▸ | LMNA | P02545 | 6/20 | 1.00 |
| ▸ | MAPT | P10636 | 6/20 | 1.00 |
| ▸ | HTR1A | P08908 | 6/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 5/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 4/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | GMNN | O75496 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | GFER | P55789 | 2/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chlorpromazine SCHEMBL8503036 | 1.00 | CYP1A2 (1.00) | CYP1A2CYP2D6LMNAMAPTHTR1A | |
| Chlorpromazine SCHEMBL5483904 | 1.00 | CYP1A2 (1.00) | CYP1A2CYP2D6LMNAMAPTHTR1A | |
| Chlorpromazine SCHEMBL29351728 | 1.00 | CYP1A2 (1.00) | CYP1A2CYP2D6LMNAMAPTHTR1A | |
| Chlorpromazine SCHEMBL29714121 | 1.00 | CYP1A2 (1.00) | CYP1A2CYP2D6LMNAMAPTHTR1A | |
| Chlorpromazine SCHEMBL41771 | 1.00 | CYP1A2 (1.00) | CYP1A2CYP2D6LMNAMAPTHTR1A | |
| Chlorpromazine SCHEMBL28234010 | 0.99 | CYP1A2 (0.97) | CYP1A2CYP2D6LMNAMAPTHTR1A | |
| Chlorpromazine SCHEMBL29367385 | 0.99 | CYP1A2 (1.00) | CYP1A2CYP2D6LMNAMAPTHTR1A | |
| Chlorpromazine SCHEMBL29358018 | 0.99 | CYP1A2 (1.00) | CYP1A2CYP2D6LMNAMAPTHTR1A | |
| Chlorpromazine SCHEMBL8321 | 0.99 | CYP1A2 (1.00) | CYP1A2CYP2D6LMNAMAPTHTR1A | |
| Chlorpromazine SCHEMBL27607834 | 0.97 | CYP1A2 (0.97) | CYP1A2CYP2D6LMNAMAPTHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210137853-A1 | METHODS OF TREATING EPILEPTIC PATIENTS WITH FENFLURAMINE | ZOGENIX INTERNATIONAL LIMITED (GB) | 2021-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210137853-A1 | METHODS OF TREATING EPILEPTIC PATIENTS WITH FENFLURAMINE | SLC6A4, SLC1A2, SLC6A2 | DRD2 172/4885DRD3 522/4885DRD4 361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.