Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Chlorpromazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 5/20 | 1.00 |
| ▸ | DRD3 known ✓ | P35462 | 5/20 | 0.97 |
| ▸ | DRD4 known ✓ | P21917 | 3/20 | 0.97 |
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 9/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 9/20 | 1.00 |
| ▸ | LMNA | P02545 | 6/20 | 1.00 |
| ▸ | MAPT | P10636 | 6/20 | 1.00 |
| ▸ | HTR1A | P08908 | 6/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 5/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 4/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | GMNN | O75496 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | GFER | P55789 | 2/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chlorpromazine SCHEMBL8503036 | 1.00 | CYP1A2 (1.00) | CYP1A2CYP2D6LMNAMAPTHTR1A | |
| Chlorpromazine SCHEMBL23326209 | 1.00 | CYP1A2 (1.00) | CYP1A2CYP2D6LMNAMAPTHTR1A | |
| Chlorpromazine SCHEMBL5483904 | 1.00 | CYP1A2 (1.00) | CYP1A2CYP2D6LMNAMAPTHTR1A | |
| Chlorpromazine SCHEMBL29351728 | 1.00 | CYP1A2 (1.00) | CYP1A2CYP2D6LMNAMAPTHTR1A | |
| Chlorpromazine SCHEMBL41771 | 1.00 | CYP1A2 (1.00) | CYP1A2CYP2D6LMNAMAPTHTR1A | |
| Chlorpromazine SCHEMBL28234010 | 0.99 | CYP1A2 (0.97) | CYP1A2CYP2D6LMNAMAPTHTR1A | |
| Chlorpromazine SCHEMBL29367385 | 0.99 | CYP1A2 (1.00) | CYP1A2CYP2D6LMNAMAPTHTR1A | |
| Chlorpromazine SCHEMBL29358018 | 0.99 | CYP1A2 (1.00) | CYP1A2CYP2D6LMNAMAPTHTR1A | |
| Chlorpromazine SCHEMBL8321 | 0.99 | CYP1A2 (1.00) | CYP1A2CYP2D6LMNAMAPTHTR1A | |
| Chlorpromazine SCHEMBL27607834 | 0.97 | CYP1A2 (0.97) | CYP1A2CYP2D6LMNAMAPTHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-121703412-A | Fentanyl, carfentanyl, cerazine and nixin four-in-one rapid detection kit based on heat-resistant antibody IgY | 中科鋆迪(杭州)生物医学有限公司 | 2026-03-20 | — | — | CN | disclosed |
| WO-2025059533-A1 | CRISPR ENZYMES AND SYSTEMS | THE BROAD INSTITUTE, INC. (US) | 2025-03-20 | — | — | WO | disclosed |
| CN-119174768-A | Application of chlorpromazine hydrochloride in preparation of acute hepatopancreatic necrosis disease resisting drugs | 山东大学 | 2024-12-24 | — | — | CN | disclosed |
| CN-118240104-A | Isatis root refined polysaccharide with immunity improving function, protein removal purification method and application thereof | 南京中医药大学 | 2024-06-25 | — | — | CN | disclosed |
| CN-113365493-B | Tomato plants resistant to tomato brown-wrinkle virus | 安莎种子公司 | 2024-03-22 | — | — | CN | disclosed |
| CN-117378604-A | Pesticide composition for stem and leaf treatment | 组合化学工业株式会社 | 2024-01-12 | — | — | CN | disclosed |
| CN-117074586-A | Method for measuring related substances in chlorpromazine hydrochloride | 万邦德制药集团有限公司 | 2023-11-17 | — | — | CN | disclosed |
| WO-2023164606-A1 | COMPOUNDS FOR MODIFYING MEIOTIC RECOMBINATION AND METHODS RELATING THERETO | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2023-08-31 | — | — | WO | disclosed |
| WO-2023150541-A1 | ANTICONVULSANT AND NEUROPROTECTIVE AGENT | THE UAB RESEARCH FOUNDATION (US) | 2023-08-10 | — | — | WO | disclosed |
| CN-115996742-A | Methods and agents for glaucoma | 奥夫博医疗创新有限公司 | 2023-04-21 | — | — | CN | disclosed |
| US-20220313656-A1 | NEW CLASS OF ANTIBIOTICS HAVING LOW MIC-VALUES TOWARDS DIFFERENT STRAINS OF BACTERIA | Københavns Universitet (DK) | 2022-10-06 | — | — | US | disclosed |
| CN-112743984-B | Ink jet recording method | 精工爱普生株式会社 | 2022-09-13 | — | — | CN | disclosed |
| US-11426413-B2 | Oral liquid compositions including chlorpromazine | Genus Lifesciences Inc. (US) | 2022-08-30 | — | — | US | disclosed |
| CN-114939106-A | Chlorpromazine hydrochloride injection and preparation method thereof | 合肥职业技术学院 | 2022-08-26 | — | — | CN | disclosed |
| CN-114729258-A | CMP polishing liquid and polishing method | 昭和电工材料株式会社 | 2022-07-08 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11426413-B2 | Oral liquid compositions including chlorpromazine | WIZ, CPNE4, CYP3A5 | DRD2 371/4885DRD3 907/4885DRD4 437/4885 |
| US-20220313656-A1 | NEW CLASS OF ANTIBIOTICS HAVING LOW MIC-VALUES TOWARDS DIFFERENT STRAINS OF BACTERIA | NR4A1, NR4A3, NR1H4 | DRD2 136/4885DRD3 33/4885DRD4 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.