Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Chlorpromazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 5/20 | 0.97 |
| ▸ | DRD3 known ✓ | P35462 | 5/20 | 0.97 |
| ▸ | DRD4 known ✓ | P21917 | 3/20 | 0.97 |
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 9/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.97 |
| ▸ | HTR1A | P08908 | 6/20 | 0.97 |
| ▸ | LMNA | P02545 | 6/20 | 0.97 |
| ▸ | MAPT | P10636 | 6/20 | 0.97 |
| ▸ | TP53 | P04637 | 6/20 | 0.97 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.97 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.97 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.97 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.97 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.97 |
| ▸ | DRD1 | P21728 | 5/20 | 0.97 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.97 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.97 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.97 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chlorpromazine SCHEMBL29367385 | 0.99 | CYP1A2 (1.00) | CYP1A2CYP2D6HTR1ALMNAMAPT | |
| Chlorpromazine SCHEMBL8321 | 0.99 | CYP1A2 (1.00) | CYP1A2CYP2D6HTR1ALMNAMAPT | |
| Chlorpromazine SCHEMBL29358018 | 0.99 | CYP1A2 (1.00) | CYP1A2CYP2D6HTR1ALMNAMAPT | |
| Chlorpromazine SCHEMBL41771 | 0.97 | CYP1A2 (1.00) | CYP1A2CYP2D6HTR1ALMNAMAPT | |
| Chlorpromazine SCHEMBL5483904 | 0.97 | CYP1A2 (1.00) | CYP1A2CYP2D6HTR1ALMNAMAPT | |
| Chlorpromazine SCHEMBL23326209 | 0.97 | CYP1A2 (1.00) | CYP1A2CYP2D6HTR1ALMNAMAPT | |
| Chlorpromazine SCHEMBL8503036 | 0.97 | CYP1A2 (1.00) | CYP1A2CYP2D6HTR1ALMNAMAPT | |
| Chlorpromazine SCHEMBL29351728 | 0.97 | CYP1A2 (1.00) | CYP1A2CYP2D6HTR1ALMNAMAPT | |
| Chlorpromazine SCHEMBL29714121 | 0.97 | CYP1A2 (1.00) | CYP1A2CYP2D6HTR1ALMNAMAPT | |
| Chlorpromazine SCHEMBL27940552 | 0.97 | CYP1A2 (0.97) | CYP1A2CYP2D6HTR1ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102264229-B | Herbicidal combination comprising dimethoxytriazinyl-substituted difluoromethanesulfonylanilines | BAYER CROPSCIENCE AG | 2013-10-30 | — | — | CN | disclosed |
| CN-1646019-A | Method for chemically decontaminating soil by applying a mixture of sulphur and complexing agents | BASF AG (DE) | 2005-07-27 | — | — | CN | disclosed |