Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Chlorpromazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 5/20 | 1.00 |
| ▸ | DRD3 known ✓ | P35462 | 5/20 | 0.97 |
| ▸ | DRD4 known ✓ | P21917 | 3/20 | 0.97 |
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 9/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 9/20 | 1.00 |
| ▸ | LMNA | P02545 | 6/20 | 1.00 |
| ▸ | MAPT | P10636 | 6/20 | 1.00 |
| ▸ | HTR1A | P08908 | 6/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 5/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 4/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | GMNN | O75496 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | GFER | P55789 | 2/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chlorpromazine SCHEMBL8503036 | 1.00 | CYP1A2 (1.00) | CYP1A2CYP2D6LMNAMAPTHTR1A | |
| Chlorpromazine SCHEMBL23326209 | 1.00 | CYP1A2 (1.00) | CYP1A2CYP2D6LMNAMAPTHTR1A | |
| Chlorpromazine SCHEMBL29351728 | 1.00 | CYP1A2 (1.00) | CYP1A2CYP2D6LMNAMAPTHTR1A | |
| Chlorpromazine SCHEMBL29714121 | 1.00 | CYP1A2 (1.00) | CYP1A2CYP2D6LMNAMAPTHTR1A | |
| Chlorpromazine SCHEMBL41771 | 1.00 | CYP1A2 (1.00) | CYP1A2CYP2D6LMNAMAPTHTR1A | |
| Chlorpromazine SCHEMBL28234010 | 0.99 | CYP1A2 (0.97) | CYP1A2CYP2D6LMNAMAPTHTR1A | |
| Chlorpromazine SCHEMBL29367385 | 0.99 | CYP1A2 (1.00) | CYP1A2CYP2D6LMNAMAPTHTR1A | |
| Chlorpromazine SCHEMBL29358018 | 0.99 | CYP1A2 (1.00) | CYP1A2CYP2D6LMNAMAPTHTR1A | |
| Chlorpromazine SCHEMBL8321 | 0.99 | CYP1A2 (1.00) | CYP1A2CYP2D6LMNAMAPTHTR1A | |
| Chlorpromazine SCHEMBL27607834 | 0.97 | CYP1A2 (0.97) | CYP1A2CYP2D6LMNAMAPTHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2906208-A1 | THERAPEUTIC TREATMENT | Sears, Douglas (US) | 2015-08-19 | — | — | EP | disclosed |
| WO-2007062198-A1 | METHODS TO ACCELERATE THE ISOLATION OF NOVEL CELL STRAINS FROM PLURIPOTENT STEM CELLS AND CELLS OBTAINED THEREBY | ADVANCED CELL TECHNOLOGY, INC. (US) | 2007-05-31 | — | — | WO | disclosed |
| EP-1014977-A1 | DIAGNOSIS OF MIGRAINE WITH AURA, DEPRESSION AND ANXIETY FROM ALLELIC VARIATIONS IN DOPAMINERGIC GENES | GLAXO GROUP LIMITED (GB) | 2000-07-05 | — | — | EP | disclosed |
| EP-1014977-A4 | DIAGNOSIS OF MIGRAINE WITH AURA, DEPRESSION AND ANXIETY FROM ALLELIC VARIATIONS IN DOPAMINERGIC GENES | GLAXO GROUP LTD (GB) | 2000-07-05 | — | — | EP | disclosed |
| WO-1998007426-A1 | DIAGNOSIS OF MIGRAINE WITH AURA, DEPRESSION AND ANXIETY FROM ALLELIC VARIATIONS IN DOPAMINERGIC GENES | GLAXO GROUP, LTD. (GB) | 1998-02-26 | — | — | WO | disclosed |
| US-3932411-A | HYPOTENSIVE, TRANQUILIZERS, SEDATIVES, ANTIEDEMIC | BOEHRINGER MANNHEIM G.M.B.H. (DT) | 1976-01-13 | — | — | US | disclosed |