Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 3/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GSR | P00390 | 1/20 | 0.32 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6855708 | 0.84 | ALDH1A1 (0.50) | POLBL3MBTL1PKMALDH1A1KDM4E | |
| SCHEMBL14050797 | 0.81 | POLB (0.39) | POLBL3MBTL1PKMALDH1A1LMNA | |
| SCHEMBL26253848 | 0.81 | PKM (0.42) | POLBL3MBTL1PKMALDH1A1LMNA | |
| SCHEMBL7447843 | 0.81 | ALDH1A1 (0.41) | POLBL3MBTL1PKMALDH1A1KDM4E | |
| SCHEMBL23327762 | 0.78 | CDK2 (0.38) | POLBL3MBTL1PKMALDH1A1LMNA | |
| SCHEMBL12953072 | 0.73 | PDE10A (0.46) | PDE10AALDH1A1KDM4EMAPTRAB9A | |
| SCHEMBL11603518 | 0.71 | KDM4E (0.54) | POLBL3MBTL1PKMALDH1A1KDM4E | |
| SCHEMBL17747503 | 0.71 | PIK3CA (0.52) | PIK3CAGSRTXNRD1 | |
| SCHEMBL3319549 | 0.70 | PDE10A (0.43) | PDE10AALDH1A1KDM4EMAPTRAB9A | |
| SCHEMBL23994248 | 0.70 | PDE10A (0.43) | PDE10AALDH1A1KDM4EMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114929226-B | TYK2 pseudokinase ligands | 温缇克斯生物科学公司 | 2024-09-27 | — | — | CN | disclosed |
| US-20230348478-A1 | TYK2 PSEUDOKINASE LIGANDS | VENTYX BIOSCIENCES, INC. | 2023-11-02 | — | — | US | disclosed |
| US-20230348478-A1 | TYK2 PSEUDOKINASE LIGANDS | VENTYX BIOSCIENCES, INC. | 2023-11-02 | — | — | US | disclosed |
| US-11753411-B2 | Substituted pyrazolo[1,5-a]pyrimidines as TYK2 pseudokinase ligands | VENTYX BIOSCIENCES, INC. (US) | 2023-09-12 | — | — | US | disclosed |
| US-11753411-B2 | Substituted pyrazolo[1,5-a]pyrimidines as TYK2 pseudokinase ligands | VENTYX BIOSCIENCES, INC. (US) | 2023-09-12 | — | — | US | disclosed |
| EP-4054581-A1 | TYK2 PSEUDOKINASE LIGANDS | Ventyx Biosciences, Inc. (US) | 2022-09-14 | — | — | EP | disclosed |
| CN-114929226-A | TYK2 pseudokinase ligands | 温缇克斯生物科学公司 | 2022-08-19 | — | — | CN | disclosed |
| US-20210139486-A1 | TYK2 PSEUDOKINASE LIGANDS | VENTYX BIOSCIENCES, INC. | 2021-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11753411-B2 | Substituted pyrazolo[1,5-a]pyrimidines as TYK2 pseudokinase ligands | TYK2, JAK1, JAK2 | POLB 1472/4885L3MBTL1 1320/4885PKM 630/4885 |
| US-20230348478-A1 | TYK2 PSEUDOKINASE LIGANDS | TYK2, JAK2, PTK2B | POLB 2160/4885L3MBTL1 2413/4885PKM 796/4885 |
| US-20210139486-A1 | TYK2 PSEUDOKINASE LIGANDS | TYK2, JAK2, PTK2B | POLB 2160/4885L3MBTL1 2413/4885PKM 796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.