Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1161336 | 0.79 | RAB9A (0.47) | RAB9AL3MBTL1KDM4EALDH1A1TSHR | |
| SCHEMBL14685292 | 0.76 | RAB9A (0.54) | RAB9AL3MBTL1TSHRLMNANPC1 | |
| SCHEMBL2454565 | 0.76 | ALDH1A1 (0.47) | RAB9AADORA2AADORA2BADORA1TDP1 | |
| SCHEMBL5459067 | 0.68 | PRMT5 (0.60) | RAB9ATDP1KDM4EALDH1A1CYP3A4 | |
| SCHEMBL6653731 | 0.68 | FGFR1 (0.50) | RAB9AKDM4EALDH1A1CYP3A4LMNA | |
| SCHEMBL10527682 | 0.66 | CYP1A2 (0.56) | RAB9AKDM4EALDH1A1TSHRCYP1A2 | |
| SCHEMBL13040554 | 0.63 | TSHR (0.53) | RAB9AADORA2AADORA2BADORA1TDP1 | |
| SCHEMBL17945998 | 0.63 | L3MBTL1 (0.50) | RAB9AL3MBTL1KDM4EALDH1A1TSHR | |
| SCHEMBL28052264 | 0.62 | CYP3A4 (0.42) | RAB9ATDP1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL10564079 | 0.61 | TDP1 (0.50) | RAB9AADORA2AADORA2BADORA1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358365-A1 | GLYCOGEN SYNTHASE KINASE-3 BETA INHIBITORS CONTAINING 7-HYDROXY-BENZOIMIDAZOLE-4-YL-METHANONE DERIVATIVES | Oncotherapy Science, Inc. (JP) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010058512-A1 | GLYCOGEN SYNTHASE KINASE-3 BETA INHIBITORS CONTAINING 7-HYDROXY-BENZOIMIDAZOLE-4-YL-METHANONE DERIVATIVES | ONCOTHERAPY SCIENCE, INC. (JP) | 2010-05-27 | — | — | WO | disclosed |