SCHEMBL2332856

SCHEMBL2332856

C[C@@H](C(N)=O)C1C(=O)Nc2ccc(Cl)cc21

nearest known ligand 0.44

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.42
CDYL2 Q8N8U2 1/20 0.41
CDYL Q9Y232 1/20 0.41
TP53 P04637 1/20 0.41
IDO1 P14902 1/20 0.41
TDO2 P48775 1/20 0.41
TGM2 P21980 1/20 0.41
CCKBR P32239 1/20 0.40
PGR P06401 2/20 0.40
CHRM1 P11229 1/20 0.40
ATM Q13315 1/20 0.39
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
SLC9A1 P19634 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6022539 1.00 MAPT (0.42) MAPTCDYL2CDYLTP53IDO1
SCHEMBL2334928 0.84 TP53 (0.42) MAPTTP53IDO1ATMMEN1
SCHEMBL2887312 0.83 CDYL2 (0.42) MAPTCDYL2CDYLTP53IDO1
SCHEMBL24020000 0.82 MAPT (0.56) MAPTCDYL2CDYLTP53CCKBR
SCHEMBL23835717 0.82 MAPT (0.56) MAPTCDYL2CDYLTP53CCKBR
SCHEMBL24447559 0.72 CDYL2 (0.47) MAPTCDYL2CDYLIDO1TDO2
SCHEMBL24112733 0.71 PGR (0.69) MAPTCDYL2CDYLTP53TGM2
SCHEMBL948578 0.71 PGR (0.69) MAPTCDYL2CDYLTP53TGM2
SCHEMBL24447980 0.70 CDYL2 (0.45) MAPTCDYL2CDYLIDO1TDO2
SCHEMBL24019652 0.70 MAPT (0.47) MAPTTP53PGRCHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2968257-A1 METHODS AND COMPOSITONS FOR IMPROVING COGNITIVE FUNCTION The Johns Hopkins University (US) 2016-01-20 EP disclosed
EP-2968220-A1 METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION Agenebio, Inc. (US) 2016-01-20 EP disclosed
EP-2919788-A1 METHODS AND COMPOSITIONS FOR TREATING SCHIZOPHRENIA The Johns Hopkins University (US) 2015-09-23 EP disclosed
WO-2014144546-A1 METHODS AND COMPOSITONS FOR IMPROVING COGNITIVE FUNCTION THE JOHNS HOPKINS UNIVERSITY (US) 2014-09-18 WO disclosed
WO-2014144801-A1 METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION AGENEBIO INC. (US) 2014-09-18 WO disclosed
WO-2014078568-A1 METHODS AND COMPOSITIONS FOR TREATING SCHIZOPHRENIA THE JOHNS HOPKINS UNIVERSITY (US) 2014-05-22 WO disclosed
EP-2533645-A1 METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION The Johns Hopkins University (US) 2012-12-19 EP disclosed
WO-2011100373-A1 METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION THE JOHNS HOPKINS UNIVERSITY (US) 2011-08-18 WO disclosed
EP-1620399-A1 INDOLONE-ACETAMIDE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES UCB, S.A. (BE) 2006-02-01 EP disclosed
WO-2004087658-A1 INDOLONE-ACETAMIDE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES UCB, S.A. (BE) 2004-10-14 WO disclosed