Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23329406 | 1.00 | SLC6A2 (0.38) | SLC6A2SLC6A4SLC6A3ALDH1A1NPSR1 | |
| SCHEMBL23329412 | 1.00 | SLC6A2 (0.38) | SLC6A2SLC6A4SLC6A3ALDH1A1NPSR1 | |
| SCHEMBL23329109 | 0.91 | YTHDC1 (0.39) | SLC6A2SLC6A4SLC6A3ALDH1A1NPSR1 | |
| SCHEMBL23304768 | 0.91 | YTHDC1 (0.39) | SLC6A2SLC6A4SLC6A3ALDH1A1NPSR1 | |
| SCHEMBL5009994 | 0.87 | YTHDC1 (0.43) | SLC6A2SLC6A4SLC6A3ALDH1A1NPSR1 | |
| SCHEMBL5006779 | 0.87 | YTHDC1 (0.43) | SLC6A2SLC6A4SLC6A3ALDH1A1NPSR1 | |
| SCHEMBL23329876 | 0.87 | YTHDC1 (0.43) | SLC6A2SLC6A4SLC6A3ALDH1A1NPSR1 | |
| Hydrochloric Acid SCHEMBL21222657 | 0.85 | YTHDC1 (0.42) | SLC6A2SLC6A4SLC6A3ALDH1A1NPSR1 | |
| Hydrochloric Acid SCHEMBL21222660 | 0.85 | YTHDC1 (0.42) | SLC6A2SLC6A4SLC6A3ALDH1A1NPSR1 | |
| SCHEMBL28017552 | 0.82 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230158024-A1 | CD38 INHIBITORS | Astellas Engineered Small Molecules US, Incorporated | 2023-05-25 | — | — | US | disclosed |
| US-20230158024-A1 | CD38 INHIBITORS | Astellas Engineered Small Molecules US, Incorporated | 2023-05-25 | — | — | US | disclosed |
| US-20230025807-A1 | CD38 INHIBITORS | Astellas Engineered Small Molecules US, Incorporated | 2023-01-26 | — | — | US | disclosed |
| WO-2021087087-A1 | N-CYCLOHEXYL-5-(THIAZOL-5-YL)-1H-INDOLE-7-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS CD38 INHIBITORS FOR INCREASING NAD+ AND FOR THE TREATMENT OF E.G. MUSCULAR DISORDERS | MITOBRIDGE INC. (US) | 2021-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230025807-A1 | CD38 INHIBITORS | CD38, GLS, IDH2 | SLC6A2 513/4885SLC6A4 1662/4885SLC6A3 738/4885 |
| US-20230158024-A1 | CD38 INHIBITORS | CD38, NQO1, NDUFAB1 | SLC6A2 974/4885SLC6A4 3684/4885SLC6A3 897/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.