Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | TDO2 | P48775 | 2/20 | 0.43 |
| ▸ | VHL | P40337 | 2/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5951254 | 0.84 | TDO2 (0.39) | DYRK1AALDH1A1TDO2MAPTHPGD | |
| SCHEMBL27475766 | 0.80 | HRH1 (0.49) | GSK3BDYRK1ACYP2A6ALDH1A1CYP1A2 | |
| SCHEMBL12969961 | 0.78 | ROCK1 (0.35) | GSK3BDYRK1A | |
| SCHEMBL1924022 | 0.77 | CYP2A6 (0.50) | MKNK1MKNK2GSK3BDYRK1ACYP2A6 | |
| SCHEMBL4789914 | 0.76 | CYP2A6 (0.48) | GSK3BDYRK1ACYP2A6ALDH1A1CYP1A2 | |
| SCHEMBL22309816 | 0.74 | DYRK1A (0.40) | GSK3BDYRK1ATDO2ALOX15 | |
| SCHEMBL18292364 | 0.73 | IDO1 (0.49) | GSK3BDYRK1ACYP2A6ALDH1A1CYP1A2 | |
| SCHEMBL17670258 | 0.72 | METAP2 (0.47) | MKNK1MKNK2GSK3BDYRK1ACYP2A6 | |
| SCHEMBL30384675 | 0.72 | METAP2 (0.47) | MKNK1MKNK2GSK3BDYRK1ACYP2A6 | |
| SCHEMBL952491 | 0.72 | MKNK1 (0.50) | MKNK1MKNK2GSK3BDYRK1ACYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11806335-B2 | Heterocyclic carboxylate compounds as glycolate oxidase inhibitors | Lilac Therapeutics, Inc. (US) | 2023-11-07 | — | — | US | disclosed |
| US-20210128532-A1 | HETEROCYCLIC CARBOXYLATE COMPOUNDS AS GLYCOLATE OXIDASE INHIBITORS | Lilac Therapeutics, Inc. | 2021-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11806335-B2 | Heterocyclic carboxylate compounds as glycolate oxidase inhibitors | UGDH, PGD, PNPO | MKNK1 3973/4885MKNK2 3939/4885GSK3B 2368/4885 |
| US-20210128532-A1 | HETEROCYCLIC CARBOXYLATE COMPOUNDS AS GLYCOLATE OXIDASE INHIBITORS | UGDH, PGD, PNPO | MKNK1 3973/4885MKNK2 3939/4885GSK3B 2368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.