Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 5/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | CA1 | P00915 | 2/20 | 0.57 |
| ▸ | CA2 | P00918 | 2/20 | 0.57 |
| ▸ | PLK1 | P53350 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.51 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25062908 | 0.85 | PKM (0.62) | PKMNPC1RAB9ACA1CA2 | |
| SCHEMBL5857541 | 0.85 | NPC1 (0.65) | PKMNPC1RAB9ACA1CA2 | |
| SCHEMBL23329444 | 0.83 | CA1 (0.54) | PKMNPC1RAB9ACA1CA2 | |
| SCHEMBL15595417 | 0.81 | KDM4E (0.70) | PKMNPC1RAB9ACA1CA2 | |
| SCHEMBL1193504 | 0.81 | NPC1 (0.65) | PKMNPC1RAB9ACA1CA2 | |
| SCHEMBL2796671 | 0.81 | ALDH1A1 (0.67) | PKMNPC1RAB9ACA1CA2 | |
| SCHEMBL8598019 | 0.81 | NPC1 (0.69) | PKMNPC1RAB9ACA1CA2 | |
| SCHEMBL28968582 | 0.79 | NPC1 (0.58) | PKMNPC1RAB9ACA1CA2 | |
| SCHEMBL16685001 | 0.79 | NPC1 (0.83) | PKMNPC1RAB9ACA1CA2 | |
| SCHEMBL11668774 | 0.79 | MMP1 (0.68) | PKMNPC1RAB9ACA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021086879-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2021-05-06 | — | — | WO | disclosed |