Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | TACR1 | P25103 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23306684 | 0.90 | TP53 (0.56) | TP53TACR1POLBGAARAB9A | |
| SCHEMBL23306683 | 0.90 | TP53 (0.56) | TP53TACR1POLBGAARAB9A | |
| SCHEMBL24925106 | 0.85 | MMP1 (0.48) | POLBCYP2C19 | |
| SCHEMBL9487303 | 0.83 | TP53 (0.61) | TP53TACR1POLBGAARAB9A | |
| SCHEMBL9487298 | 0.83 | TP53 (0.61) | TP53TACR1POLBGAARAB9A | |
| SCHEMBL9146866 | 0.81 | TP53 (0.60) | TP53TACR1POLBGAARAB9A | |
| SCHEMBL9385728 | 0.81 | TP53 (0.60) | TP53TACR1POLBGAARAB9A | |
| SCHEMBL9385733 | 0.81 | TP53 (0.60) | TP53TACR1POLBGAARAB9A | |
| SCHEMBL9146870 | 0.81 | TP53 (0.60) | TP53TACR1POLBGAARAB9A | |
| SCHEMBL11559927 | 0.81 | TP53 (0.60) | TP53TACR1POLBGAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230028516-A1 | PRODRUGS OF ITACONATE AND METHYL ITACONATE | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY AS CR V.V.I. (CZ) | 2023-01-26 | — | — | US | disclosed |
| US-20230025922-A1 | USE OF ITACONATE AND ITS DERIVATIVES/ANALOGUES TO INDUCE HAIR GROWTH | THE JOHNS HOPKINS UNIVERSTY | 2023-01-26 | — | — | US | disclosed |
| WO-2021087083-A1 | USE OF ITACONATE AND ITS DERIVATIVES/ANALOGUES TO INDUCE HAIR GROWTH | THE JOHNS HOPKINS UNIVERSITY (US) | 2021-05-06 | — | — | WO | disclosed |
| WO-2021087082-A1 | PRODRUGS OF ITACONATE AND METHYL ITACONATE | THE JOHNS HOPKINS UNIVERSITY (US) | 2021-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230025922-A1 | USE OF ITACONATE AND ITS DERIVATIVES/ANALOGUES TO INDUCE HAIR GROWTH | LRBA, HADHA, IMPDH1 | TP53 1122/4885TACR1 4166/4885POLB 1132/4885 |
| US-20230028516-A1 | PRODRUGS OF ITACONATE AND METHYL ITACONATE | HADHA, IMPDH1, CYP27A1 | TP53 1074/4885TACR1 3904/4885POLB 1832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.