Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1754354 | 0.89 | MAPT (0.43) | MAPTSMN1; SMN2LMNATP53EPHX2 | |
| SCHEMBL1754182 | 0.87 | EPHX2 (0.47) | SMN1; SMN2LMNATP53EPHX2NR1H4 | |
| SCHEMBL2333581 | 0.81 | HPGD (0.43) | TP53ROCK2ROCK1 | |
| SCHEMBL1754176 | 0.79 | TRPV1 (0.45) | MAPTSMN1; SMN2LMNATP53EPHX2 | |
| SCHEMBL1753966 | 0.79 | TRPV1 (0.45) | MAPTSMN1; SMN2LMNATP53EPHX2 | |
| SCHEMBL2108295 | 0.77 | LMNA (0.44) | MAPTLMNATP53EPHX2NR1H4 | |
| SCHEMBL14378424 | 0.73 | NR1H4 (0.47) | MAPTSMN1; SMN2LMNATP53EPHX2 | |
| SCHEMBL1753973 | 0.72 | TAS1R3 (0.46) | LMNAROCK2ROCK1 | |
| SCHEMBL3292156 | 0.72 | TAS1R3 (0.46) | LMNAROCK2ROCK1 | |
| SCHEMBL1753950 | 0.72 | TAS1R3 (0.46) | LMNAROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222631-B1 | SUBSTITUTED PHENYLMETHYL BICYCLOCARBOXYAMIDE COMPOUNDS | PFIZER (US) | 2011-08-17 | — | — | EP | claimed |