Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | NAAA | Q02083 | 1/20 | 0.34 |
| ▸ | DGKA | P23743 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28492324 | 0.87 | ALDH1A1 (0.50) | HCAR2ALDH1A1LMNANAAADGKA | |
| SCHEMBL7041660 | 0.81 | — | — | |
| SCHEMBL805650 | 0.81 | HCAR2 (0.40) | HCAR2ALDH1A1LMNAESR1CHRM1 | |
| SCHEMBL805664 | 0.81 | HCAR2 (0.40) | HCAR2ALDH1A1LMNAESR1CHRM1 | |
| SCHEMBL17617139 | 0.81 | HCAR2 (0.40) | HCAR2ALDH1A1LMNAESR1CHRM1 | |
| SCHEMBL28473113 | 0.81 | TSHR (0.41) | ALDH1A1NAAADGKATSHRTDP1 | |
| SCHEMBL5728295 | 0.80 | MAPT (0.38) | HCAR2ALDH1A1LMNANAAADGKA | |
| SCHEMBL6739568 | 0.79 | HCAR2 (0.39) | HCAR2ALDH1A1LMNANAAADGKA | |
| SCHEMBL1421691 | 0.79 | HCAR2 (0.39) | HCAR2ALDH1A1LMNAESR1CHRM1 | |
| SCHEMBL3905507 | 0.79 | ALDH1A1 (0.46) | HCAR2ALDH1A1LMNAESR1CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8247609-B2 | Aminoacid derivatives containing a disulfanyl group in the form of mixed disulfanyl and aminopeptidase N inhibitors | Pharamleads (FR) | 2012-08-21 | — | — | US | disclosed |
| US-8247608-B2 | Aminoacid derivatives containing a disulfanyl group in the form of mixed disulfanyl and aminopeptidase N inhibitors | PHARMALEADS (FR) | 2012-08-21 | — | — | US | disclosed |
| EP-1940818-B1 | AMINOACID DERIVATIVES CONTAINING A DISULFANYL GROUP IN THE FORM OF MIXED DISULFANYL AND AMINOPEPTIDASE N INHIBITORS | PHARMALEADS (FR) | 2011-08-24 | — | — | EP | disclosed |
| US-20090131509-A1 | Aminoacid Derivatives Containing a Disulfanyl Group in the form of Mixed Disulfanyl and Aminopeptidase N Inhibitors | PHARMALEADS (FR) | 2009-05-21 | — | — | US | disclosed |
| US-20090012153-A1 | AMINOACID DERIVATIVES CONTAINING A DISULFANYL GROUP IN THE FORM OF MIXED DISULFANYL AND AMINOPEPTIDASE N INHIBITORS | PHARMALEADS (FR) | 2009-01-08 | — | — | US | disclosed |
| EP-0900803-B1 | PROCESS FOR THE PREPARATION OF 1-ALKOXY-1-TRIMETHYLSILYLOXYCYCLOPROPANES | IHARA CHEMICAL IND CO (JP) | 2003-03-26 | — | — | EP | disclosed |
| US-5994572-A | REACTING MICROGRANULAR METALLIC SODIUM DISPERSED IN A HYDROCARBON SOLVENT WITH A BETA-HALOGENOCARBOXYLIC ACID ESTER | IHARA CHEMICAL INDUSTRY CO., LTD (JP) | 1999-11-30 | — | — | US | disclosed |
| EP-0900803-A1 | PROCESS FOR THE PREPARATION OF 1-ALKOXY-1-TRIMETHYLSILYLOXYCYCLOPROPANES | IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) | 1999-03-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131509-A1 | Aminoacid Derivatives Containing a Disulfanyl Group in the form of Mixed Disulfanyl and Aminopeptidase N Inhibitors | HRH4, OPRL1, CNR2 | HCAR2 175/4885ALDH1A1 617/4885LMNA 4779/4885 |
| US-20090012153-A1 | AMINOACID DERIVATIVES CONTAINING A DISULFANYL GROUP IN THE FORM OF MIXED DISULFANYL AND AMINOPEPTIDASE N INHIBITORS | HRH4, CNR2, OPRM1 | HCAR2 156/4885ALDH1A1 591/4885LMNA 4699/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.