Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KLK7 | P49862 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.33 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.33 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2337495 | 0.93 | LPAR1 (0.40) | ALDH1A1KDM4EHPGDSMN1; SMN2LPAR1 | |
| SCHEMBL2337997 | 0.91 | ALDH1A1 (0.43) | ALDH1A1KLK7KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL3705976 | 0.91 | ALDH1A1 (0.35) | ALDH1A1HPGDSMN1; SMN2ALOX15HTT | |
| SCHEMBL2340991 | 0.89 | KLK7 (0.38) | ALDH1A1KLK7KDM4ESMN1; SMN2MAPT | |
| SCHEMBL3702504 | 0.88 | ALDH1A1 (0.37) | ALDH1A1KLK7KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL2335475 | 0.87 | KDM4E (0.39) | ALDH1A1KDM4ESMN1; SMN2MAPTHTT | |
| SCHEMBL3705660 | 0.85 | SYK (0.35) | ALDH1A1KDM4ESMN1; SMN2ALOX15HTT | |
| SCHEMBL2333294 | 0.84 | LPAR1 (0.43) | ALDH1A1KDM4EHPGDSMN1; SMN2MAPT | |
| SCHEMBL2337987 | 0.84 | LPAR1 (0.40) | LPAR1LPAR2LPAR3 | |
| SCHEMBL3715778 | 0.84 | KDM4E (0.38) | ALDH1A1KDM4ESMN1; SMN2MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358688-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |
| WO-2010077883-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |