Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 2/20 | 0.40 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.39 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.35 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 3/20 | 0.35 |
| ▸ | RXRB | P28702 | 3/20 | 0.35 |
| ▸ | RXRG | P48443 | 3/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.33 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2341313 | 0.93 | LPAR1 (0.40) | LPAR1LPAR2LPAR3DGAT1SOAT1 | |
| SCHEMBL3705976 | 0.93 | ALDH1A1 (0.35) | LPAR1LPAR2LPAR3USP2POLB | |
| SCHEMBL2337495 | 0.91 | LPAR1 (0.40) | LPAR1LPAR2LPAR3DGAT1SOAT1 | |
| SCHEMBL2343129 | 0.90 | LPAR1 (0.39) | LPAR1LPAR2LPAR3RXRARXRB | |
| SCHEMBL2335539 | 0.89 | LPAR1 (0.45) | LPAR1LPAR2LPAR3DGAT1SOAT1 | |
| SCHEMBL2341053 | 0.86 | LPAR1 (0.42) | LPAR1LPAR2LPAR3DGAT1SOAT1 | |
| SCHEMBL3712524 | 0.85 | LPAR1 (0.42) | LPAR1LPAR2LPAR3DGAT1SOAT1 | |
| SCHEMBL3702504 | 0.85 | ALDH1A1 (0.37) | LPAR1LPAR2LPAR3POLBSLC26A6 | |
| SCHEMBL1245262 | 0.85 | THRB (0.37) | DGAT1SOAT1RXRARXRBRXRG | |
| SCHEMBL2336970 | 0.85 | LPAR1 (0.44) | LPAR1LPAR2LPAR3DGAT1SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358688-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |
| WO-2010077883-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |