Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23344653 | 0.84 | KDM4E (0.41) | KDM4ELRRK2MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL23344648 | 0.78 | MEN1 (0.43) | KDM4ELRRK2CYP2C19MEN1KMT2A | |
| SCHEMBL14376028 | 0.77 | ALDH1A1 (0.45) | CYP11B1CYP11B2KDM4EALDH1A1HPGD | |
| SCHEMBL26341911 | 0.75 | KDM4E (0.47) | CYP11B1CYP11B2KDM4EALDH1A1OPRK1 | |
| SCHEMBL765394 | 0.74 | LRRK2 (0.44) | CYP11B1CYP11B2KDM4EOPRK1LRRK2 | |
| SCHEMBL19145279 | 0.74 | KDM4E (0.51) | CYP11B1CYP11B2KDM4EALDH1A1HPGD | |
| SCHEMBL19145547 | 0.74 | KDM4E (0.54) | KDM4EALDH1A1HSD17B10OPRK1LRRK2 | |
| SCHEMBL23344780 | 0.72 | ALDH1A1 (0.43) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL14376035 | 0.72 | PDE10A (0.52) | ALDH1A1LRRK2CYP2C19MEN1KMT2A | |
| SCHEMBL23344647 | 0.71 | CYP1A2 (0.45) | LRRK2PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210139456-A1 | PYRIDAZINE COMPOUNDS FOR INHIBITING NAV1.8 | LIEBER INSTITUTE, INC | 2021-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210139456-A1 | PYRIDAZINE COMPOUNDS FOR INHIBITING NAV1.8 | SCN8A, SCN5A, SCN2A | CYP11B1 3430/4885CYP11B2 2712/4885KDM4E 3022/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.