Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | KHK | P50053 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15831846 | 0.82 | ALDH1A1 (0.44) | ALDH1A1HPGDKHKKDM4EHSD17B10 | |
| SCHEMBL20369843 | 0.76 | ALDH1A1 (0.54) | ALDH1A1HPGDKHKKDM4EHSD17B10 | |
| SCHEMBL24042938 | 0.73 | ALDH1A1 (0.48) | ALDH1A1HPGDKHKKDM4EHSD17B10 | |
| SCHEMBL23344677 | 0.72 | CYP11B1 (0.45) | ALDH1A1HPGDKHKKDM4EHSD17B10 | |
| SCHEMBL23344647 | 0.72 | CYP1A2 (0.45) | TRPV1 | |
| SCHEMBL4500475 | 0.71 | CYP2A13 (0.43) | ALDH1A1KDM4EHSD17B10TRPV1POLB | |
| SCHEMBL20365554 | 0.71 | ALDH1A1 (0.46) | ALDH1A1HPGDKHKKDM4EHSD17B10 | |
| SCHEMBL23344648 | 0.71 | MEN1 (0.43) | KDM4EKMT2AMEN1GAA | |
| SCHEMBL6821415 | 0.70 | ALDH1A1 (0.58) | ALDH1A1HPGDKHKKDM4EHSD17B10 | |
| SCHEMBL24611970 | 0.70 | POLB (0.47) | ALDH1A1HPGDKHKKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210139456-A1 | PYRIDAZINE COMPOUNDS FOR INHIBITING NAV1.8 | LIEBER INSTITUTE, INC | 2021-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210139456-A1 | PYRIDAZINE COMPOUNDS FOR INHIBITING NAV1.8 | SCN8A, SCN5A, SCN2A | ALDH1A1 3396/4885HPGD 1577/4885KHK 3371/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.