Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN5 | P54829 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23326539 | 0.78 | PTPN5 (0.51) | PTPN5CYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL23326510 | 0.77 | PTPN5 (0.50) | PTPN5CYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL29861499 | 0.77 | PTPN5 (0.50) | PTPN5CYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL17681595 | 0.72 | CYP2C19 (0.65) | PTPN5CYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL30977684 | 0.71 | MEN1 (0.60) | PTPN5CYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL12126017 | 0.71 | MEN1 (0.60) | PTPN5CYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL23326784 | 0.71 | PTPN5 (0.44) | PTPN5CYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL29861148 | 0.71 | PTPN5 (0.44) | PTPN5CYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL20357414 | 0.70 | GPR35 (0.43) | CYP1A2CYP2C9CYP2C19ALDH1A1GPR35 | |
| SCHEMBL16771000 | 0.68 | ALDH1A1 (0.38) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210139517-A1 | BICYCLIC HETEROARYL COMPOUNDS AND USES THEREOF | Revolution Medicines, Inc. | 2021-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210139517-A1 | BICYCLIC HETEROARYL COMPOUNDS AND USES THEREOF | SOST, SOS1, SOS2 | PTPN5 883/4885CYP1A2 2086/4885CYP2C9 3034/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.