Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL4592112 | 1.00 | — | — | |
| Bicarbonate SCHEMBL21598431 | 1.00 | — | — | |
| Bicarbonate SCHEMBL2122167 | 1.00 | — | — | |
| Bicarbonate SCHEMBL29280952 | 0.96 | CA1 (0.39) | CA1CA2CA9FFAR3LCK | |
| Bicarbonate SCHEMBL27806680 | 0.96 | CA1 (0.39) | CA1CA2CA9FFAR3LCK | |
| Bicarbonate SCHEMBL2782263 | 0.96 | — | — | |
| Bicarbonate SCHEMBL27963055 | 0.96 | CA1 (0.46) | CA1CA2CA9FFAR3LCK | |
| Bicarbonate SCHEMBL7096240 | 0.92 | CA1 (0.42) | CA1CA2CA9FFAR3LCK | |
| Bicarbonate SCHEMBL4654017 | 0.92 | — | — | |
| Bicarbonate SCHEMBL4322728 | 0.92 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101170915-B | Acyl derivatives of curcumin, demethoxycurcumin, bisdemethoxycurcumin or curcuminisoxazolide and their use as animal feed additives | DSM IP ASSETS BV | 2012-05-23 | — | — | CN | disclosed |
| US-8003686-B2 | Aryl derivatives of curcumin, demethoxycurcumin, bisdemethoxycurcumin or curcuminisoxazolide and their use as animal feed additives | DSM IP ASSETS B.V. (NL) | 2011-08-23 | — | — | US | disclosed |
| US-20100010232-A1 | Aryl derivatives of curcumin, demethoxycurcumin, bisdemethoxycurcumin or curcuminisoxazolide and their use as animal feed additives | DSM IP ASSETS B.V. (NL) | 2010-01-14 | — | — | US | disclosed |
| CN-101170915-A | Acyl derivatives of curcumin, demethoxycurcumin, bisdemethoxycurcumin or curcuminisoxazolide and their use as animal feed additives | DSM IP ASSETS BV (NL) | 2008-04-30 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100010232-A1 | Aryl derivatives of curcumin, demethoxycurcumin, bisdemethoxycurcumin or curcuminisoxazolide and their use as animal feed additives | AADAC, ARNT, PIGS | CA1 3177/4885CA2 2830/4885CA9 3059/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.